A Prospective Study of Infantile Hemangiomas with a Focus on Incidence and Risk Factors
A Prospective Study of Infantile Hemangiomas with a Focus on Incidence and Risk Factors
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DOI：
10.1111/j.1525-1470.2011.01568.x
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发表时间：
2011-11-01
影响因子：
1.5
通讯作者：
Wargon, Orli
中科院分区：
文献类型：
--
作者：
Dickison, Philippa;Christou, Elizabeth;Wargon, Orli
婴儿血管瘤 (IH) 是婴儿期最常见的肿瘤，估计有 4% 的婴儿会发生这种情况。此前仅发表了两项健康人群 IH 发病率研究，且两项研究均在出生后第一周内进行。目的是确定澳大利亚新生儿群体中 IH 的发病率并描述危险因素。所有来到一家拥有 200 个床位的妇产医院产后病房的妇女都被要求填写一份调查问卷。记录了产妇病史和出生细节的详细信息。出院后 3 周和 6 周，我们向所有同意的母亲发送了两封后续电子邮件，询问她们的孩子是否患有 IH。据报告患有 IH 的婴儿到诊所就诊以确认诊断。从 1,034 名母亲和 1,065 名婴儿收集了详细信息； 28 名（2.6%）婴儿出现 IH。与未患 IH 的婴儿相比，患 IH 的婴儿更有可能是女性 (p < 0.001)、出生体重低 (p = 0.020)、胎龄 < 37 周 (p = 0.005) 以及通过体外受精 (IVF) 受孕 (p = 0.001)。出生后 6 周时 IH 的发生率为 2.6%。
Infantile hemangiomas (IHs) are the most common tumor of infancy and have been estimated to occur in 4% of infants. Only two previous incidence studies of IH in a healthy population have been published, and both of these were performed in the first week of life. The objective was to identify the incidence of IH in an Australian neonatal population and characterize the risk factors. All women who presented to the postnatal ward in a 200-bed maternity hospital were asked to complete a questionnaire. Details of maternal history and birth details were recorded. Two follow-up emails 3 and 6 weeks after discharge were sent to all mothers who consented, asking if their baby had developed an IH. Babies reported to have an IH were seen in clinic to confirm the diagnosis. Details were collected from 1,034 mothers of 1,065 babies; 28 (2.6%) of the infants developed IH. Babies that developed IH were more likely to be female (p < 0.001), have a low birth weight (p = 0.020), be born at a gestational age of < 37 weeks (p = 0.005), and be conceived through in vitro fertilization (IVF) (p = 0.001) than those who did not. The incidence of IH at 6 weeks of life was 2.6%.