ProGRP is a possible tumor marker for patients with Ewing sarcoma.
ProGRP is a possible tumor marker for patients with Ewing sarcoma.
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DOI：
10.2220/biomedres.36.273
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发表时间：
2015-08
期刊：
影响因子：
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通讯作者：
K. Yamaguchi;H. Katagiri;Mitsuru Takahashi;Y. Ishida;A. Ono;Toshiaki Takahashi;K. Ohshima;T. Mochizuki;K. Urakami;Koji Muramatsu;T. Kameya;I. Ito;T. Nakajima
中科院分区：
文献类型：
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作者：
K. Yamaguchi;H. Katagiri;Mitsuru Takahashi;Y. Ishida;A. Ono;Toshiaki Takahashi;K. Ohshima;T. Mochizuki;K. Urakami;Koji Muramatsu;T. Kameya;I. Ito;T. Nakajima
我们分析了尤文肉瘤患者的血清ProGRP水平，发现9例患者中有5例水平升高;其值范围与小细胞肺癌局限性疾病患者相同。尤文肉瘤以外的骨和软组织恶性肿瘤患者的血清ProGRP水平不升高。免疫组化结果显示，在2例血清ProGRP水平升高的尤文肉瘤组织中检测到ProGRP样免疫反应阳性，提示ProGRP是尤文肉瘤肿瘤细胞的产物。提示血清ProGRP可作为尤文肉瘤的特异性肿瘤标志物。由于ProGRP是小细胞肺癌（一种典型的神经内分泌癌）肿瘤细胞的主要激素产物，因此本研究为尤文肉瘤具有神经内分泌分化提供了证据。
We analyzed serum ProGRP levels in patients with Ewing sarcoma, and found that 5 out of 9 patients had elevated levels; the values range equally with those of patients with limited disease of small-cell lung carcinoma. Serum ProGRP levels in patients with bone and soft tissue malignancies other than Ewing sarcoma are not elevated. Immunohistochemical studies demonstrated that ProGRP-like immunoreactivities were detected in Ewing sarcoma tissues obtained from 2 patients with elevated serum ProGRP levels, suggesting that ProGRP is a product of tumor cells of Ewing sarcoma. These results indicate that serum ProGRP could serve as a specific tumor marker for Ewing sarcoma. Since ProGRP is a major hormonal product of tumor cells of small-cell lung carcinoma, a typical neuroendocrine carcinoma, it is reasonable to postulate that the present study provides an evidence for Ewing sarcoma to possess neuroendocrine differentiation.