THE DROSOPHILA-MELANOGASTER GENE LETHAL(3)73AH ENCODES A RING FINGER PROTEIN HOMOLOGOUS TO THE ONCOPROTEINS MEL-18 AND BMI-1
THE DROSOPHILA-MELANOGASTER GENE LETHAL(3)73AH ENCODES A RING FINGER PROTEIN HOMOLOGOUS TO THE ONCOPROTEINS MEL-18 AND BMI-1
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DOI：
10.1016/0378-1119(95)00326-2
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发表时间：
1995-10-03
期刊：
影响因子：
3.5
通讯作者：
NOTHINGER, R
中科院分区：
文献类型：
--
作者：
IRMINGERFINGER, I;NOTHINGER, R
果蝇（Drosophila melanogaster）（Dm）基因致死（3）73 Ah，在蛹晚期是必需的，编码一种具有新的富含Cys序列基序的蛋白质，这是环指蛋白的典型特征。氨基酸序列比较显示，整个致死性73 Ah序列与哺乳动物癌基因mel-18和bmi-1的基因产物以及zeste基因中的Posterior sex combs和Suppressor编码的Dm蛋白的含锌指的N-末端区域具有惊人的同源性。（3）73 Ah基因位于与性别决定基因Transformer共享3 '端非翻译序列的转录密集区。其转录受时间和空间调控，在成年雌性中表达最多。在所有阶段，mRNA都可以定位于脂肪体，此外，还可以定位于成年女性的卵巢。
The Drosophila melanogaster (Dm) gene lethal(3)73Ah, essential at the late pupal stage, encodes a protein with a novel Cys-rich sequence motif, typical for ring-finger proteins. Amino-acid sequence comparison revealed a striking homology of the entire lethal(3)73Ah sequence to the gene products of the mammalian oncogenes, mel-18 and bmi-1, and to the zinc-finger-containing N-terminal region of the Dm proteins encoded by the Posterior sex combs and Suppressor two of zeste genes. The lethal(3)73Ah gene is located in a densely transcribed region sharing 3'-untranslated sequences with the adjacent sex-determining gene, transformer. Its transcription is temporally and spatially regulated with maximal expression in adult females. In all stages the mRNA can be localized to the fat body and, in addition, to the ovaries of adult females.