Mammalian chemosensory receptors.
Mammalian chemosensory receptors.
复制标题
哺乳动物化学感应受体。
DOI：
10.1097/00001756-200201210-00003
复制
发表时间：
2002
期刊：
影响因子：
1.7
通讯作者：
Sullivan,SusanL
中科院分区：
文献类型：
--
作者：
Sullivan,SusanL
化学感应受体对于许多哺乳动物物种的生存至关重要，其基因可占哺乳动物基因组的 1%。气味、味觉和犁鼻受体的发现和功能特征的快速发展，人类基因组序列的可用性进一步加速了这一速度。已提出由小鼠体内超过 1000 个基因组成的 5 个多基因家族来编码功能性化学感受器。尽管所有化学感受器基因家族都编码 G 蛋白偶联受体，但它们在很大程度上是不相关的，并且专门用于处理不同的化学感应模式。利用这些家族的成员作为分子探针，人们对这些感觉系统在外周和大脑中编码信息所使用的不同组织策略有了深入的了解。
Chemosensory receptors are critical for the survival of many mammalian species, and their genes can comprise up to 1% of mammalian genomes. Odorant, taste, and vomeronasal receptors are being discovered and functionally characterized at a rapid pace which has been further accelerated by the availability of the human genome sequence. Five multigene families, consisting of> 1000 genes in the mouse, have been proposed to encode functional chemoreceptors. Although all of the chemoreceptor gene families encode G-protein coupled receptors, they are largely unrelated and uniquely specialized for the processing of different chemosensory modalities. Using members of the families as molecular probes, great insights are being gained into the different organizational strategies used by these sensory systems to encode information in both the periphery and the brain.