Regulation of endocytic traffic by Rho family GTPases
Regulation of endocytic traffic by Rho family GTPases
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DOI：
10.1016/s0962-8924(99)01710-9
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发表时间：
2000-03-01
影响因子：
19
通讯作者：
Mellor, H
中科院分区：
文献类型：
--
作者：
Ellis, S;Mellor, H
内吞作用是一个复杂而高效的过程，涉及从小分子到活化的信号受体到整个微生物的货物的摄取和加工。内吞途径的调节知之甚少。最近的证据表明，Rho GTdR家族的信号蛋白密切参与内吞交通，提供新的见解的控制机制，管理这一进程。
Endocytosis is a complicated yet highly efficient process that involves the uptake and processing of cargoes, ranging from small molecules, to activated signalling receptors, to whole microorganisms. Regulation of endocytic pathways is poorly understood. Recent evidence suggests that the Rho GTPase family of signalling protein is intimately involved in endocytic traffic, providing novel insights into the control mechanisms that govern this process.