Ex Vivo Systems to Study Chondrogenic Differentiation and Cartilage Integration.
Ex Vivo Systems to Study Chondrogenic Differentiation and Cartilage Integration.
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DOI：
10.3390/jfmk6010006
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发表时间：
2021-01-05
影响因子：
--
通讯作者：
Stoddart MJ
中科院分区：
文献类型：
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作者：
Monaco G;El Haj AJ;Alini M;Stoddart MJ
关节软骨损伤和修复是一个日益重要的问题。虽然关节软骨缺损很常见，但由于其自我修复能力差（主要是由于其无血管性），因此存在独特的临床挑战。迫切需要更好地研究和理解细胞愈合机制，以实现更有效的软骨再生疗法。这篇文章的目的是描述软骨的关键特征，这是使用组织工程软骨结构和离体系统建模。这些模型已被用于研究软骨分化和研究软骨整合到周围组织的机制。该综述强调了关节软骨修复在健康和患病关节的关键再生原则。使用共培养模型和新型生物反应器设计，再生的基础与最近的最佳治疗干预措施的努力相一致。
Articular cartilage injury and repair is an issue of growing importance. Although common, defects of articular cartilage present a unique clinical challenge due to its poor self-healing capacity, which is largely due to its avascular nature. There is a critical need to better study and understand cellular healing mechanisms to achieve more effective therapies for cartilage regeneration. This article aims to describe the key features of cartilage which is being modelled using tissue engineered cartilage constructs and ex vivo systems. These models have been used to investigate chondrogenic differentiation and to study the mechanisms of cartilage integration into the surrounding tissue. The review highlights the key regeneration principles of articular cartilage repair in healthy and diseased joints. Using co-culture models and novel bioreactor designs, the basis of regeneration is aligned with recent efforts for optimal therapeutic interventions.