Cholesterol hydroperoxides and their degradation mechanism.
Cholesterol hydroperoxides and their degradation mechanism.
复制标题
DOI：
10.1007/978-94-007-7920-4_7
复制
发表时间：
2014
影响因子：
--
通讯作者：
J. Terao
中科院分区：
文献类型：
--
作者：
J. Terao
胆固醇是构成生物膜和血浆脂蛋白的一种可氧化脂质。胆固醇氢过氧化物（cholo - ooh）是胆固醇受到活性氧攻击的主要产物。特别是单线态分子氧与胆固醇反应生成胆固醇5α-氢过氧化物作为主要的氢过氧化物。胆碱ooh可能在生物系统中积累，因为它抵抗谷胱甘肽依赖的酶解毒反应。它们的降解产物（包括羟基胆固醇和7-酮胆固醇）参与了氧化甾醇的病理生理功能。高活性胆固醇5,6-二醇存在于动脉粥样硬化病变中，可来源于胆固醇5α-氢过氧化物的降解。胆碱ooh本身可能影响生物膜的脂筏，从而导致信号转导途径的改变。
Cholesterol is one of the oxidizable lipids constituting biomembranes and plasma lipoproteins. Cholesterol hydroperoxides (Chol-OOH) are the primary products if cholesterol is subjected to attack by reactive oxygen species. In particular, singlet molecular oxygen reacts with cholesterol to yield cholesterol 5α-hydroperoxide as the major hydroperoxide species. Chol-OOH may accumulate in biological systems because of its resistance to glutathione-dependent enzymatic detoxification reactions. Their degradation products (including hydroxycholesterol and 7-ketocholesterol) participate in the pathophysiological functions of oxysterols. Highly reactive cholesterol 5,6-secosterol present in atherosclerotic lesions can be derived from the degradation of cholesterol 5α-hydroperoxide. Chol-OOH themselves may affect the lipid rafts of biomembranes, thereby leading to the modification of signal transduction pathways.