High-Resolution High Kinetic Energy Ion Mobility Spectrometer Based on a Low-Discrimination Tristate Ion Shutter
High-Resolution High Kinetic Energy Ion Mobility Spectrometer Based on a Low-Discrimination Tristate Ion Shutter
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DOI：
10.1021/acs.analchem.7b04586
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发表时间：
2018-05-01
影响因子：
7.4
通讯作者：
Zimmermann, Stefan
中科院分区：
文献类型：
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作者：
Kirk, Ansgar T.;Grube, Denise;Zimmermann, Stefan
高动能离子淌度光谱仪 (HiKE-IMS) 可在几秒钟内进行灵敏的痕量气体分析，通过在减压和高电场强度下运行，缓解了标准离子淌度光谱仪的许多缺点。然而，这些优势通常是以分辨率降低为代价的，原始设备场强降低至 120 Td 时，分辨率从最高 75 降至 50。在这项工作中，我们提出了 HiKE-IMS 分辨率的扩展理论和新颖的三态离子快门原理，能够实现 1 μs 的初始离子包宽度，而不会产生明显的迁移率歧视。这种超短的注入时间可以将 HiKE-IMS 的分辨率提高到 140，以适应大范围的降低电场强度。凭借这种分辨率，可以分离苯、甲苯和二甲苯混合物中产生的所有离子种类。此外，140 的分辨率足以在高电场强度下部分分离同位素异体。
High kinetic energy ion mobility spectrometry (HiKE-IMS) allows for sensitive trace gas analysis within seconds, mitigating many disadvantages of standard ion mobility spectrometers through operation at reduced pressure and high electric field strengths. However, these advantages usually come at the cost of reduced resolving power, ranging from a maximum of 75 down to 50 at a reduced field strength of 120 Td for the original device. In this work, we present an extended theory for HiKE-IMS resolving power and a novel tristate ion shutter principle able to achieve initial ion packet widths of 1 mu s without significant mobility discrimination. Such an ultrashort injection time allows for improving the resolving power of the HiKE-IMS to 140 for a wide range of reduced electric field strengths. With this resolving power, separating all ion species generated from a mixture of benzene, toluene, and xylene is possible. Furthermore, a resolving power of 140 is sufficient to partially separate isotopologues under high electric field strengths.