A Polydopamine Nanoparticle-Knotted Poly(ethylene glycol) Hydrogel for On-Demand Drug Delivery and Chemo-photothermal Therapy
A Polydopamine Nanoparticle-Knotted Poly(ethylene glycol) Hydrogel for On-Demand Drug Delivery and Chemo-photothermal Therapy
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DOI：
10.1021/acs.chemmater.6b05192
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发表时间：
2017-01
影响因子：
8.6
通讯作者：
Xing Wang;Changping Wang;Xinyu Wang;Yitong Wang;Qiang Zhang;Yiyun Cheng
中科院分区：
文献类型：
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作者：
Xing Wang;Changping Wang;Xinyu Wang;Yitong Wang;Qiang Zhang;Yiyun Cheng
水凝胶在药物递送中表现出显著的益处，例如局部递送、数天或甚至数周的连续药物释放以及改善的生物利用度和最小化的副作用。在这里，我们报告了聚多巴胺（PDA）纳米颗粒打结聚（乙二醇）（PEG）水凝胶按需给药和联合化疗光热治疗。通过凝胶中的π-π相互作用负载在PDA纳米颗粒上的抗癌药物如7-乙基-10-羟基喜树碱（SN 38）在生理条件下表现出最小的泄漏，并且可以在近红外光暴露时以按需方式释放。该水凝胶显示出优异的生物相容性，并且在四个月的植入中不会引起任何异物反应。体内实验结果表明，载SN 38的PDA纳米颗粒打结PEG水凝胶可以通过联合化疗-光热疗法有效抑制肿瘤生长。这种智能水凝胶将有利于各种疾病的一系列局部治疗。
Hydrogels have exhibited remarkable benefits in drug delivery such as local delivery, days or even weeks of continuous drug release with improved bioavailability, and minimized adverse effects. Here we report a polydopamine (PDA) nanoparticle-knotted poly(ethylene glycol) (PEG) hydrogel for on-demand drug delivery and combined chemo-photothermal therapy. Anticancer drugs such as 7-ethyl-10-hydroxycamptothecin (SN38) loaded on PDA nanoparticles via π–π interaction in the gel exhibit minimal leakage at physiological conditions and could be released in an on-demand fashion upon near-infrared light exposure. The hydrogel shows excellent biocompatibility and does not induce any foreign-body reaction over a four-month implantation. The in vivo results demonstrate that the PDA nanoparticle-knotted PEG hydrogel loaded with SN38 could efficiently suppress tumor growth by a combined chemo-photothermal therapy. This smart hydrogel would benefit a series of local treatments for diverse diseases.