DYNAMICS OF WOUND CLOSURE AND ITS ROLE IN THE PROGRAMMING OF PLANARIAN REGENERATION .1. BLASTEMA EMERGENCE
DYNAMICS OF WOUND CLOSURE AND ITS ROLE IN THE PROGRAMMING OF PLANARIAN REGENERATION .1. BLASTEMA EMERGENCE
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DOI：
10.1111/j.1440-169x.1979.00195.x
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发表时间：
1979-01-01
影响因子：
2.5
通讯作者：
CHANDEBOIS, R
中科院分区：
文献类型：
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作者：
CHANDEBOIS, R
体内观察[用三角涡虫]表明，伤口边缘通过肌肉收缩紧密接触，并在横切后立即通过第一意图融合。当肌肉松弛时，伤口上皮细胞随后通过表皮细胞的拉伸形成。背侧和腹侧半厚度碎片在体外通过其前缘或后缘相关联。表皮只有在自由边界被压成紧密接触时才通过最初的意图融合。不同部位和大小的芽基由背、腹表皮之间的缝合线在其被拉伸的地方形成。引起拉伸的相反的力特别是由于碎片的卷起或它们在被迫融合后的松弛。与先前的假设相反，简单的融合背和腹表皮是不足以启动芽出现。拉伸的需要可以解释为，某些表皮细胞靠近对侧的组织，形成类似于一个边缘的过渡表皮。由于这一远端水平的形成接近横切，中间再生将随之发生，其第一步将是芽基出现。
Observations in vivo [with Dugesia lugubris] show that the edges of the wound are brought into close contact by muscle contraction and fuse by first intention immediately after transection. The wound epithelium forms later by the stretching of the epidermal cells when the muscles relax. Dorsal and ventral half-thickness fragments were associated in vitro by their anterior or posterior edges. The epidermis only fuses by first intention when the free borders are pressed into close contact. Blastemas of various localizations and sizes are formed from the suture between dorsal and ventral epidermis, in those places where it has been stretched. The opposing forces which cause the stretching are particularly due to the rolling-up of the fragments or to their relaxation after they have been forced to fuse. Contrary to what was previously assumed, the simple fusion of dorsal and ventral epidermis is not sufficient to initiate blastema emergence. The need for stretching may be explained by the fact that certain epidermal cells are brought close to tissues of the opposite side, forming a transitional epidermis analogous to one edge. As a result of the formation of this distal level close to transection, intercalary regeneration would ensue, whose first step would be blastema emergence.