Effect of CCR2 chemokine receptor polymorphism on HIV type 1 mother-to-child transmission and child survival in Western Kenya.
Effect of CCR2 chemokine receptor polymorphism on HIV type 1 mother-to-child transmission and child survival in Western Kenya.
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CCR2 趋化因子受体多态性对肯尼亚西部 1 型 HIV 母婴传播和儿童生存的影响。
DOI：
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发表时间：
2005
影响因子：
1.5
通讯作者：
R. Lal
中科院分区：
文献类型：
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作者：
Kimberly C. Brouwer;Chunfu Yang;Shalini Parekh;L. Mirel;Y. Shi;J. Otieno;A. Lal;R. Lal
非洲尚未深入探讨CCR2基因多态性对HIV-1母婴传播和疾病进展的影响。由于这种假定的HIV辅助受体的CCR2-64I变异与成人艾滋病进展缓慢有关，本研究旨在研究CCR2基因多态与肯尼亚西部地区HIV-1围产期传播和儿童存活的关系。对445例HIV阳性母亲及其婴儿进行CCR2基因分型。无论母亲的病毒载量、病毒亚型、免疫状态或胎盘疟疾状态如何，母亲和儿童的CCR2-64I等位基因频率均不受HIV-1传播状况的影响。对于围产期感染HIV的婴儿(n=78)，CCR2基因与感染时的病毒载量或2年随访的存活率之间没有关联。我们的结果没有表明CCR2-64I对肯尼亚儿童围产期艾滋病毒传播和生存的影响。
The effect of CCR2 polymorphism on HIV-1 mother-to-child transmission and disease progression has not been explored in depth within Africa. As the CCR2-64I variant of this putative HIV coreceptor has been associated with slower progression to AIDS in adults, the current study was undertaken to examine the relationship between CCR2 polymorphism and HIV-1 perinatal transmission and child survival in western Kenya. CCR2 genotype was determined for 445 HIV-seropositive mothers and their infants. The CCR2-64I allele frequency of both mothers and children did not differ by HIV-1 transmission status, regardless of maternal viral load, viral subtype, immune status, or placental malaria status. For infants who acquired HIV perinatally (n = 78), there was no association between CCR2 genotype and viral load upon infection or survival rate over the 2-year follow-up. Our results do not indicate an effect of CCR2-64I on perinatal HIV transmission and survival in Kenyan children.