Kinetic Evaluation of Spin Trapping Rate Constants of New CYPMPO-type Spin Traps for Superoxide and Other Free Radicals
Kinetic Evaluation of Spin Trapping Rate Constants of New CYPMPO-type Spin Traps for Superoxide and Other Free Radicals
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DOI：
10.1515/zpch-2014-0610
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发表时间：
2015-03-01
影响因子：
2.5
通讯作者：
Kotake, Yashige
中科院分区：
文献类型：
--
作者：
Sueishi, Yoshimi;Kamogawa, Erisa;Kotake, Yashige
CYPMPO（5-（2,2-二甲基-1,3-丙氧基环磷酰基）-5-甲基-1-吡咯啉 N-氧化物）是一种含磷自旋捕获剂，可用于水性介质。使用动态ESR自旋捕获技术，我们评估了两种新合成的CYPMPO型自旋捕获剂的自由基捕获速率常数，包括2,2-二丁基取代的CYPMPO（DBCYP）和5-苯基取代的CYPMPO（PhCYP）。我们研究了五种自由基的自旋捕获，即超氧化物、羟基自由基、烷氧基自由基、烷基过氧自由基和甲基自由基。除超氧化物外，DBCYP和PhCYP的自旋捕获速率常数与CYPMPO相当，范围为CYPMPO相应速率常数的43.9%至101%。然而，PhCYP 针对超氧化物的自旋捕获速率常数比 CYPMPO 高 44%。结果表明，DBCYP 和 PhCYP 可能是在水性或非水性介质中与 CYPMPO 一样有用的自旋陷阱。
CYPMPO (5-(2,2-dimethyl-1,3-propoxyl cyclophosphoryl)-5-methyl-1-pyrroline N-oxide) is a phosphorus containing spin trap that has been useful in aqueous media. Using a kinetic ESR spin trapping technique, we evaluated free radical trapping rate constants of two newly synthesized CYPMPO-type spin traps, including 2,2-dibutyl-substituted CYPMPO (DBCYP) and 5-phenyl-substituted CYPMPO (PhCYP). We investigated the spin trapping of five free radical species, i.e., superoxide, hydroxyl radical, alkoxyl radical, alkyl peroxyl radical and methyl radical. Other than superoxide, spin trapping rate constants of DBCYP and PhCYP are comparable to CYPMPO, ranging from 43.9% to 101% of CYPMPO's corresponding rate constants. However, PhCYP's spin-trapping rate constant against superoxide was 44% higher than that of CYPMPO. The results indicate that DBCYP and PhCYP may be the spin traps as useful as CYPMPO either in aqueous or non-aqueous medium.