Cortical vein thrombosis in adult patients of cerebral venous sinus thrombosis correlates with poor outcome and brain lesions: a retrospective study.
Cortical vein thrombosis in adult patients of cerebral venous sinus thrombosis correlates with poor outcome and brain lesions: a retrospective study.
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脑静脉窦血栓形成成年患者的皮质静脉血栓形成与不良预后和脑部病变相关：一项回顾性研究。
DOI：
10.1186/s12883-017-0995-y
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发表时间：
2017-12-15
期刊：
影响因子：
2.6
通讯作者：
Zeng J
中科院分区：
文献类型：
--
作者：
Liang J;Chen H;Li Z;He S;Luo B;Tang S;Shang W;Zeng J
皮质静脉血栓形成（CVT）在成人脑静脉窦血栓形成（CVST）患者中很少受到关注。本研究旨在探讨成人CVST患者合并CVT的临床和影像学特征。从2009年5月至2016年5月，我们招募了44例成人CVST患者（发病1个月内确诊;年龄33.8 ± 14.0岁，28例男性）。CVT的初步确诊采用计算机断层静脉造影和磁共振成像序列的对比增强三维磁化准备梯度回波快速采集。合并CVT的患者被分为CVT组;否则，患者被分为非CVT组。比较两组患者的临床影像学特征。CVT组包括27例患者（61.4%），非CVT组包括17例患者（38.6%）。CVT组患者癫痫发作（63.0%比11.8%）、局灶性神经功能障碍（44.4%比5.9%）和意识障碍（33.3%比0）的发生率高于非CVT组（P <0.05）。CVT组患者出院时改良兰金量表（mRS）评分（中位数2，范围1 - 4）高于非CVT组患者（中位数0，范围0 - 4）（P <0.001）。静脉梗死（63.0%对11.8%）、脑实质出血（40.7%对5.9%）和蛛网膜下腔出血（22.2%对0）在CVT组中的发生率高于非CVT组（P <0.05）。这项研究表明，伴随CVT是成人CVST患者的常见结果，与严重的临床表现、不良的短期结局和脑部病变相关。本文的在线版本（10.1186/s12883 - 017 - 0995-y）包含补充材料，可供授权用户使用。
Cortical vein thrombosis (CVT) receives little attention in adult patients with cerebral venous sinus thrombosis (CVST). This study aimed to investigate the clinical and radiological features of adult CVST patients with concomitant CVT. From May 2009 to May 2016, we recruited 44 adult CVST patients (diagnosed within 1 month of onset; 33.8 ± 14.0 years of age, 28 males). CVT was primarily confirmed using computed tomography venography and magnetic resonance imaging sequence of contrast enhanced three dimensions magnetization prepared rapid acquisition with gradient echo. Patients with concomitant CVT were divided into the CVT group; otherwise, the patients were placed into the non-CVT group. The clinico-radiological characteristics were compared between the two groups. The CVT group included 27 patients (61.4%), and the non-CVT group included 17 patients (38.6%). Seizure (63.0% versus 11.8%), focal neurological deficits (44.4% versus 5.9%), and consciousness disorders (33.3% versus 0) occurred more frequently in the patients in the CVT group than in those of the non-CVT group (P < 0.05). The modified Rankin Scale (mRS) score at discharge was higher for the CVT group patients (median 2, range 1–4) than for the non-CVT group patients (median 0, range 0–4) (P < 0.001). Venous infarction (63.0% versus 11.8%), parenchymal hemorrhage (40.7% versus 5.9%), and subarachnoid hemorrhage (22.2% versus 0) were identified more frequently in the CVT group than in the non-CVT group (P < 0.05). This study demonstrates that concomitant CVT is a common finding in adult patients with CVST and is associated with severe clinical manifestations, poor short-term outcomes, and brain lesions. The online version of this article (10.1186/s12883-017-0995-y) contains supplementary material, which is available to authorized users.
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