EFFECT OF GARLIC OIL EXTRACT ON GLUTATHIONE-REDUCTASE LEVELS IN RATS FED ON HIGH SUCROSE AND ALCOHOL DIETS - A POSSIBLE MECHANISM OF THE ACTIVITY OF THE OIL
EFFECT OF GARLIC OIL EXTRACT ON GLUTATHIONE-REDUCTASE LEVELS IN RATS FED ON HIGH SUCROSE AND ALCOHOL DIETS - A POSSIBLE MECHANISM OF THE ACTIVITY OF THE OIL
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DOI：
10.1007/bf01116245
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发表时间：
1986-10-01
影响因子：
4
通讯作者：
ADOGA, GI
中科院分区：
文献类型：
--
作者：
ADOGA, GI
本文研究了高蔗糖、高酒精饲料喂养的白色白化病大鼠，饲喂大蒜油对谷胱甘肽还原酶活性的影响。而高糖和酒精饮食导致肝脏，肾脏和血清中谷胱甘肽还原酶活性显着增加，大蒜油的存在使水平恢复到接近正常。有人提出，大蒜油的这种作用机制涉及的活性成分，二烯丙基二硫化物，它在交换反应中与酶和底物，如谷胱甘肽还原酶和谷胱甘肽，其中含有巯基相互作用。
The effect on glutathione reductase activities of feeding garlic oil to white albino rats maintained on high sucrose and alcohol diets was studied. Whereas high sucrose and alcohol diets resulted in significant increases in the activity of glutathione reductase in liver, kidneys and serum, the presence of garlic oil restored the levels to near normal. It is proposed that the mechanism of this action of garlic oil involves the active principle, diallyl disulphide, which interacts in an exchange reaction with enzymes and substrates such as glutathione reductase and glutathione which contain thiol groups.