Health of children born to mothers who had preeclampsia: a population-based cohort study
Health of children born to mothers who had preeclampsia: a population-based cohort study
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DOI：
10.1016/j.ajog.2009.06.060
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发表时间：
2009-09-01
影响因子：
9.8
通讯作者：
Olsen, Jorn
中科院分区：
文献类型：
--
作者：
Wu, Chun S.;Nohr, Ellen A.;Olsen, Jorn
OBJECTIVE: We assessed whether preeclampsia correlates with the long-term postnatal health of the offspringSTUDY DESIGN: We conducted a populalion-based cohort study of 1,618,481 singletons born in Denmark (1978-2004) with up to 27 years of follow-up. We used Cox regression to estimate the associations between preeclampsia and long-term health outcomes of the offspringRESULTS: Children born at term exposed to preeclampsia had an increased risk of a variety of diseases, such as endocrine, nutritional, and metabolic diseases (incidence rate ratio, 16, 95% confidence interval, 15-1.7), and diseases of the blood and blood-forming organs (incidence rate ratio, 1 5; 95% confidence interval, 13-18) Children born preterm exposed to preeclampsia had a similar pattern of hospitalizations compared with the children born preterm unexposed to preeclampsia, although they had a decreased risk of cerebral palsy (incidence rate ratio, 0 7, 95% confidence interval, 06-09)CONCLUSION: Preeclampsia was associated with an increased risk of being hospitalized for a number of diseases, especially in the children born at term.
