Does physical activity attenuate, or even eliminate the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than one million men and women
Does physical activity attenuate, or even eliminate the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than one million men and women
复制标题
DOI：
--
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
U. Ekelund;J. Steene-Johannessen;W. Brown;Morten Wang Fagerland;Lancet Sedentary Behaviour Working Group
中科院分区：
文献类型：
--
作者：
U. Ekelund;J. Steene-Johannessen;W. Brown;Morten Wang Fagerland;Lancet Sedentary Behaviour Working Group
大量的久坐行为与几种慢性病和死亡率的风险增加有关。然而，目前还不清楚体育活动是否会减弱甚至消除长时间坐着的有害影响。我们纳入了16项研究的数据，其中14项是通过对从数据库建立到2015年10月的6个数据库的系统审查而确定的，另外两项是可获得相关数据的其他未发表的研究。所有的研究数据都按照一个协调的方案进行了分析，该方案将报告的每日坐着时间和看电视时间分别归入四个标准化组，并将体力活动分为四个分位数。然后，我们结合所有研究的数据(N=1,005,791)，分析每日久坐时间和体力活动与全因死亡率的联合和分层关系，并使用COX回归估计总风险比。我们用看电视的时间而不是每天坐着的时间重复了这些分析。
High amounts of sedentary behaviour have been associated with increased risks for several chronic conditions and mortality. However, it is unclear whether physical activity attenuates or even eliminates the detrimental effects of prolonged sitting. We included data from 16 studies, of which 14 were identified through a systematic review of six databases from database inception until October 2015 and two were additional unpublished studies where pertinent data were available. All study data were analysed according to a harmonised protocol, which categorized reported daily sitting time and TV-viewing time into four standardised groups each, and physical activity into quartiles. We then combined data across all studies (N=1,005,791) to analyse the joint and stratified associations of daily sitting time and physical activity with all-cause mortality, and estimated summary hazard ratios using Cox regression. We repeated these analyses using TV-viewing time instead of daily sitting time.