Significance of the Ro antigen system.
Significance of the Ro antigen system.
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Ro抗原系统的意义。
DOI：
10.1007/bf00915372
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发表时间：
1986
影响因子：
9.1
通讯作者：
Reichlin,M
中科院分区：
文献类型：
--
作者：
Reichlin,M
关于 Ro/SSA 和 La/SSB 抗原抗体的知识已大大扩展。这些抗体的识别可能在 25 年前就已经实现，但它们的大分子结构、临床关联和遗传关系直到过去 7 年才被揭示。显然，这些抗体在 SLE 和 SS 的疾病学中占有特殊的地位，并且在某些情况下（例如新生儿 LE），抗体发挥直接致病作用，而在其他情况下（例如血管炎、肾炎、SS），组织损伤可能是由于免疫复合物沉积在血管结构上造成的。当然，后面的问题将是未来几年研究的活跃领域。如果近期进展继续下去，本次审查中提出的许多问题应该很快就会有明确的答案。
Knowledge about antibodies to the Ro/SSA and La/SSB antigens has expanded greatly. Recognition of these antibodies was probably achieved 25 years ago but their macromolecular structure, clinical associations, and genetic relationships have come to light only in the past 7 years. It seems clear that these antibodies have a special place in the nosology of SLE and SS and that in certain instances (e.g., neonatal LE) the antibodies play a direct pathogenic role, while in other circumstances (e.g., vasculitis, nephritis, SS) tissue damage might result from immune complex deposition on vascular structures. Certainly, the latter problems will be active areas of investigation in the coming years. If the pace of recent progress continues, many of the questions raised in this review should soon have clear answers.