Internalization of ionotropic glutamate receptors in response to mGluR activation
Internalization of ionotropic glutamate receptors in response to mGluR activation
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DOI：
10.1038/nn746
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发表时间：
2001-11-01
影响因子：
25
通讯作者：
Bear, MF
中科院分区：
文献类型：
--
作者：
Snyder, EM;Philpot, BD;Bear, MF
Activation of group 1 metabotropic glutamate receptors (mGIuRs) stimulates dendritic protein synthesis and long-term synaptic depression (LTD), but it remains unclear how these effects are related. Here we provide evidence that a consequence of mGluR activation in the hippocampus is the rapid loss of both AMPA and NMDA receptors from synapses. Like mGluR-LTD, the stable expression of this change requires protein synthesis. These data suggest that expression of mGluR-LTD is at least partly postsynaptic, and that a functional consequence of dendritic protein synthesis is the regulation of glutamate receptor trafficking.
