Age of onset and the prospectively observed course of illness in bipolar disorder
Age of onset and the prospectively observed course of illness in bipolar disorder
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DOI：
10.1016/j.jad.2012.08.031
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发表时间：
2013-03-20
影响因子：
6.6
通讯作者：
Keller, Martin B.
中科院分区：
文献类型：
--
作者：
Coryell, William;Fiedorowicz, Jess;Keller, Martin B.
背景资料：为了测试的有效性，发病年龄分组在双相情感障碍通过使用前瞻性观察的时间在mood episodes.Methods：发病年龄范围从以前的混合物分析被用来分为427个人与双相I型或双相II型障碍的早期，中期和晚发型组。这些进行了比较的比例周抑郁和躁狂或轻躁狂在一个平均（SD）的前瞻性随访17.4（8.4）years.Results：如预测，最早发病的一组报告在摄入更多的以前的事件，自杀企图和恐慌发作。早期发病的年龄，但不是当前的年龄，是预测抑郁发作的时间在随访期间显着更多，但在躁狂或轻躁狂发作的时间没有预测。局限性：这是一个自然的研究，没有控制的治疗，所以治疗的变异性可能会掩盖预测因素和结果之间的关系。发病年龄进行了回顾性测定，并受到不准确的recall.Conclusions：发病年龄早传达，在适度的程度上，预后较差的抑郁症发病率表示。(C)2012 Elsevier B.V.保留所有权利。
Background: To test the validity of age-of-onset grouping in bipolar disorder through the use of prospectively observed time in mood episodes.Methods: Age-of-onset ranges from prior admixture analyses were used to divide 427 individuals with bipolar I or bipolar II disorders into early-, middle- and late- onset groups. These were compared by the proportions of weeks depressed and manic or hypomanic during a mean (SD) prospective follow-up of 17.4 (8.4) years.Results: As predicted, the group with the earliest onsets reported at intake more previous episodes, suicide attempts and panic attacks. An early age of onset, but not current age, was predictive of significantly more time in depressive episodes during follow-up but was not predictive of time in manic or hypomanic episodes.Limitations: This was a naturalistic study with no control of treatment so variability in treatment may have obscured relationships between predictors and outcomes. Age of onset was retrospectively determined and subject to inaccuracies in recall.Conclusions: An early age of onset conveys, to a modest degree, a poorer prognosis as expressed in more depressive morbidity. (C) 2012 Elsevier B.V. All rights reserved.