Detection, stimulation, and inhibition of neuronal signals with high-density nanowire transistor arrays
Detection, stimulation, and inhibition of neuronal signals with high-density nanowire transistor arrays
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DOI：
10.1126/science.1128640
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发表时间：
2006-08-25
期刊：
影响因子：
56.9
通讯作者：
Lieber, Charles M.
中科院分区：
文献类型：
--
作者：
Patolsky, Fernando;Timko, Brian P.;Lieber, Charles M.
我们报告的电性能的混合结构组成的阵列的纳米线场效应晶体管集成与活的哺乳动物神经元的单个轴突和树突，其中每个纳米结可用于空间分辨，高灵敏度的检测，刺激，和/或抑制神经元信号的传播。轴突-神经元连接的阵列使得能够同时测量沿着沿着单个轴突和树突传播的信号的速率、幅度和形状。在阵列中的神经轴突连接的配置，作为输入和输出，使得可能的控制研究的局部电和化学刺激的信号传播的部分到完全抑制。此外，在每个神经元至少50个“人工突触”的水平上整合和测试了神经轴突连接阵列。
We report electrical properties of hybrid structures consisting of arrays of nanowire field-effect transistors integrated with the individual axons and dendrites of live mammalian neurons, where each nanoscale junction can be used for spatially resolved, highly sensitive detection, stimulation, and/or inhibition of neuronal signal propagation. Arrays of nanowire-neuron junctions enable simultaneous measurement of the rate, amplitude, and shape of signals propagating along individual axons and dendrites. The configuration of nanowire-axon junctions in arrays, as both inputs and outputs, makes possible controlled studies of partial to complete inhibition of signal propagation by both local electrical and chemical stimuli. In addition, nanowire-axon junction arrays were integrated and tested at a level of at least 50 "artificial synapses'' per neuron.