Effects of conditioned fear stress on serotonin neurotransmission and freezing behavior in rats
Effects of conditioned fear stress on serotonin neurotransmission and freezing behavior in rats
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DOI：
10.1016/s0014-2999(99)00441-0
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发表时间：
1999-07-28
影响因子：
5
通讯作者：
Koyama, T
中科院分区：
文献类型：
--
作者：
Hashimoto, S;Inoue, T;Koyama, T
为了阐明大脑神经元系统在焦虑的精神病理学中的作用，我们使用在体微透析方法检测了心理应激（条件性恐惧应激）对大鼠内侧前额叶皮层细胞外5-羟色胺（5-HT）浓度的影响，同时观察了条件性恐惧应激诱导的冻结行为（焦虑的一个指标）。条件性恐惧应激增加了内侧前额叶皮层细胞外5-HT水平，并且这种5-HT水平的增加之后是冻结行为的解决。一个剂量为10毫克/公斤的选择性5-羟色胺再摄取抑制剂，西酞普兰，在暴露于条件性恐惧应激前60分钟给药，立即和有力地增加细胞外5-羟色胺浓度，减少冻结行为。这些结果强烈表明，大脑5-HT神经传递的促进减少焦虑，这与临床报道，选择性5-HT再摄取抑制剂是有效的治疗焦虑症。(C)1999 Elsevier Science B. V.保留所有权利。
In an attempt to clarify the role of the brain serotonergic system in the psychopathology of anxiety, we examined the effect of a psychological stress, conditioned fear stress, on extracellular serotonin (5-hydroxytryptamine, 5-HT) concentrations in the rat medial prefrontal cortex using the method of in vivo microdialysis, while simultaneously observing conditioned fear stress-induced freezing behavior, an index of anxiety. Conditioned fear stress increased extracellular 5-HT levels in the medial prefrontal cortex, and this 5-HT level increase was followed by a resolution of the freezing behavior. A dose of 10 mg/kg of a selective 5-HT reuptake inhibitor, citalopram, administered 60 min before exposure to conditioned fear stress increased extracellular 5-HT concentrations immediately and potently, reducing freezing behavior. These findings strongly suggest that facilitation of brain 5-HT neurotransmission decreases anxiety, which is in agreement with the clinical reports that selective 5-HT reuptake inhibitors are effective in the treatment of anxiety disorders. (C) 1999 Elsevier Science B.V. All rights reserved.