Effects of green tea on gene expression of hepatic gluconeogenic enzymes in vivo
Effects of green tea on gene expression of hepatic gluconeogenic enzymes in vivo
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DOI：
10.1055/s-2004-832659
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发表时间：
2004-11-01
期刊：
影响因子：
2.7
通讯作者：
Isemura, M
中科院分区：
文献类型：
--
作者：
Koyama, Y;Abe, K;Isemura, M
最近有报道称，绿茶中的主要多酚成分表没食子儿茶素没食子酸酯(EGCG)模拟了胰岛素的细胞效应，包括在细胞培养体系中对限速糖异生酶基因表达的抑制作用。我们发现，服用含有EGCG的绿茶可以降低小鼠肝脏中葡萄糖异生酶、磷酸烯醇式丙酮酸羧酸激酶和葡萄糖-6-磷酸酶的mRNAs水平。研究还发现，EGCG单独可以下调这些酶的基因表达，但不能下调姜黄素或槲皮素。这项研究的结果支持了这样一种观点，即绿茶的摄入可能有助于预防糖尿病。
It has recently been reported that the major green tea polyphenolic constituent, epigallocatechin 3-gallate (EGCG), mimics the cellular effects of insulin including the reductive effect on the gene expression of rate-limiting gluconeogenic enzymes in a cell culture system. We show that administration of green tea that contains EGCG caused a reduction in the level of mRNAs for gluconeogenic enzymes, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in the mouse liver. EGCG alone was also found to down-regulate the gene expression of these enzymes but not so curcumin or quercetin. The results of this study support the idea that green tea intake may be beneficial in the prevention of diabetes mellitus.