The risk factor of false-negative and false-positive for T-SPOT.TB in active tuberculosis
The risk factor of false-negative and false-positive for T-SPOT.TB in active tuberculosis
复制标题
活动性结核病T-SPOT.TB假阴性和假阳性的危险因素
DOI：
10.1002/jcla.22273
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发表时间：
2018-02-01
影响因子：
2.7
通讯作者：
Li, Yan
中科院分区：
文献类型：
--
作者：
Di, Li;Li, Yan
目的T-SPOT.TB是鉴别肺结核、肺外结核和潜伏性结核的一种很有前途的诊断工具，但影响T-SPOT.TB结果的因素尚不清楚。方法2016年1月1日至2017年1月22日在武汉大学人民医院共招募了349例患者，其中98例为结核病患者，251例为非结核病患者，接受了T-SPOT.TB（Oxford Immunotec Ltd）治疗。结果T-SPOT.TB的特异性和敏感性分别为92.83%（233/251; 95%CI 0.8872-0.9557）和83.67%（82/98; 95%CI 0.7454-0.9010）。结核性脑膜炎患者更易出现假阴性结果（OR 17.4，95%CI 3.068-98.671; P
ObjectivesT-SPOT.TB is a promising diagnosis tool to identify both pulmonary tuberculosis and extrapulmonary tuberculosis, as well as latent tuberculosis; however, the factors that affect the results of T-SPOT.TB remains unclear. In this study, we aim to figure out the risk factor of T-SPOT.TB for active TB.MethodsA total of 349 patients were recruited between January 1st, 2016 and January 22st, 2017 at Renmin Hospital of Wuhan University, including 98 subjects with TB and 251 subjects with non-TB disease, and received T-SPOT.TB (Oxford Immunotec Ltd). Statistics were analyzed by SPSS 19.0 using logistic regression.ResultsThe overall specificity and sensitivity of the T-SPOT.TB was 92.83% (233/251; 95%CI 0.8872-0.9557) and 83.67% (82/98; 95%CI 0.7454-0.9010), respectively. Patients with tuberculous meningitis were more likely to have false-negative results (OR 17.4, 95%CI 3.068-98.671; P