Increased Neurotropic Threat from Burkholderia pseudomallei Strains with a B. mallei-Like Variation in the bimA Motility Gene, Australia
Increased Neurotropic Threat from Burkholderia pseudomallei Strains with a B. mallei-Like Variation in the bimA Motility Gene, Australia
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DOI：
10.3201/eid2305.151417
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发表时间：
2017-05-01
影响因子：
11.8
通讯作者：
Ketheesan, Natkunam
中科院分区：
文献类型：
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作者：
Morris, Jodie L.;Fane, Anne;Ketheesan, Natkunam
神经类鼻疽病是一种严重的、具有潜在致命性的伯克霍尔德氏菌感染。最近，我们报道了来自澳大利亚的假鼻疽临床分离株的一部分已经增强了毒力并有可能传播到中枢神经系统。在这项研究中，我们证明了这个亚集具有基于肌动蛋白的运动性基因BIMA的类似B.Mallei的序列变异。与具有典型BIMA等位基因的假鼻疽杆菌分离株相比，在实验模型中，含有类马来杆菌变异的分离株在吞噬细胞中的持久性增加，毒力增强，在包括脑和脊髓在内的多个组织中迅速系统性传播和复制。这些发现突出了BIMA变异对假鼻疽杆菌感染的疾病进展的影响，并就对人类健康构成的神经毒性威胁的程度而言，具有相当大的临床和公共卫生影响。
Neurologic melioidosis is a serious, potentially fatal form of Burkholderia pseudomallei infection. Recently, we reported that a subset of clinical isolates of B. pseudomallei from Australia have heightened virulence and potential for dissemination to the central nervous system. In this study, we demonstrate that this subset has a B. mallei-like sequence variation of the actin-based motility gene, bimA. Compared with B. pseudomallei isolates having typical bimA alleles, isolates that contain the B. mallei-like variation demonstrate increased persistence in phagocytic cells and increased virulence with rapid systemic dissemination and replication within multiple tissues, including the brain and spinal cord, in an experimental model. These findings highlight the implications of bimA variation on disease progression of B. pseudomallei infection and have considerable clinical and public health implications with respect to the degree of neurotropic threat posed to human health.