Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions.
Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions.
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DOI：
10.1016/j.cell.2016.10.022
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发表时间：
2016-11-17
期刊：
影响因子：
64.5
通讯作者：
Moore, Kateri
中科院分区：
文献类型：
--
作者：
Bernitz, Jeffrey M.;Kim, Huen Suk;MacArthur, Ben;Sieburg, Hans;Moore, Kateri
细胞计数和记忆其分裂的能力可能是在发育、衰老和疾病过程中发生的许多变化的基础。我们追踪了整个成人生活中慢循环造血干细胞（HSC）的累积分裂历史。这揭示了一部分很少分裂的HSC，其包含老化HSC区室中的所有长期HSC（LT-HSC）活性。在成年期，这个种群异步地完成四个可追踪的对称自我更新分裂，以扩大其规模，然后进入休眠状态。我们表明，扩展的机制涉及逐步延长细胞分裂之间的时间，与长期的再生潜力失去了第五次分裂。我们的数据还表明，年龄相关的表型变化的HSC车厢内的分区历史依赖。这些结果表明，造血干细胞积累离散的记忆阶段，在其分裂的历史，并提供证据的作用，细胞记忆在造血干细胞老化。HSC计数并记住它们分裂的次数，以限制细胞分裂的次数，这可能是HSC老化的基础。
The ability of cells to count and remember their divisions could underlie many alterations that occur during development, aging, and disease. We tracked the cumulative divisional history of slow-cycling hematopoietic stem cells (HSCs) throughout adult life. This revealed a fraction of rarely dividing HSCs that contained all the long-term HSC (LT-HSC) activity within the aging HSC compartment. During adult life, this population asynchronously completes four traceable symmetric self-renewal divisions to expand its size before entering a state of dormancy. We show that the mechanism of expansion involves progressively lengthening periods between cell divisions, with long-term regenerative potential lost upon a fifth division. Our data also show that age-related phenotypic changes within the HSC compartment are divisional history dependent. These results suggest that HSCs accumulate discrete memory stages over their divisional history and provide evidence for the role of cellular memory in HSC aging. HSCs count and remember the number of times they have divided to limit the number of cell divisions, a mechanism that may underlie HSC aging.
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影响因子：
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作者：
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发表时间：
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期刊：
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影响因子：
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