Tonsillectomy Does Not Reduce Upper Respiratory Infections: A National Cohort Study
Tonsillectomy Does Not Reduce Upper Respiratory Infections: A National Cohort Study
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DOI：
10.1371/journal.pone.0169264
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发表时间：
2016-12-30
期刊：
影响因子：
3.7
通讯作者：
Ahn, Soon-Hyun
中科院分区：
文献类型：
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作者：
Choi, Hyo Geun;Park, Bumjung;Ahn, Soon-Hyun
目的本研究的目的是比较扁桃体切除术和非扁桃体切除术参与者（对照组）术后上呼吸道感染（uri）的就诊情况。方法采用韩国健康保险审查和评估服务中心的国家队列研究，选择1:4匹配（年龄、性别、收入、地区和术前URI就诊）扁桃体切除术参与者（5831名）和对照参与者（23324名）。URI术后随访时间为术后1 - 9年。采用等效性检验。差异等效边际（扁桃体切除-对照组组）设为-0.5 ~ 0.5。结果扁桃体切除术组与对照组术后1 ~ 9年随访无统计学差异（-0.5 < 95% CI < 0.5）。扁桃体切除术组和对照组的URI就诊次数从术前的5.5/2年逐渐减少到术后1年的2.1年和术后9年的1.4年。在亚组分析（儿童Vs青少年和成人；术前URI罕见Vs频繁）中，扁桃体切除术组和对照组的URI术后就诊次数没有差异（-0.5 < 95% CI < 0.5）。结论扁桃体切除并不会减少URI的术后就诊次数，而且无论是否切除扁桃体，URI都会随着时间的推移而减少。
ObjectivesThe objective of this study was to compare post-operative visits for upper respiratory infections (URIs) between tonsillectomy and non-tonsillectomy participants (controls).MethodsUsing the national cohort study from the Korean Health Insurance Review and Assessment Service, 1: 4 matched (age, sex, income, region, and pre-operative URI visit) tonsillectomy participants (5,831) and control participants (23,324) were selected. Post-operative visits for URI were measured from 1 to 9 years post-op. The equivalence test was used. The margin of equivalence of the difference (Tonsillectomy-Control group group) was set to -0.5 to 0.5.ResultsThere was no difference between the tonsillectomy and control group in 1-to 9-year post-op visits (-0.5 < 95% CI of difference < 0.5). URI visits gradually decreased from 5.5/2 years (pre-op) to 2.1/year (at 1 year post-op) and 1.4/year (at 9 years post-op) in both tonsillectomy and control groups. In the subgroup analysis (children Vs adolescent and adults; rare Vs frequent pre-operative URI), there was no difference in the number of post-op visits for URI between the tonsillectomy and control groups (-0.5 < 95% CI of difference < 0.5).ConclusionTonsillectomy does not provide a decrease in the number of post-operative visits for URI, and URI decreased over time whether or not a tonsillectomy was performed.