Association of gag multimers with filamentous actin during equine infectious anemia virus assembly
Association of gag multimers with filamentous actin during equine infectious anemia virus assembly
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DOI：
10.2174/157016207780636542
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发表时间：
2007-05-01
影响因子：
1
通讯作者：
Montelaro, Ronald C.
中科院分区：
文献类型：
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作者：
Chen, Chaoping;Jin, Jing;Montelaro, Ronald C.
肌动蛋白细胞骨架在逆转录病毒装配中的作用一直被推测。然而，肌动蛋白促进组装过程的具体机制仍然难以捉摸。我们以前证明了不同的影响，实验修改的肌动蛋白动力学油病毒粒子生产的马传染性贫血病毒（EIAV），慢病毒相关的HIV-1，这表明在逆转录病毒生产的肌动蛋白动力学的参与。在目前的研究中，我们使用双分子荧光互补（BiFC）来揭示亲密的（
A role for the actin cytoskeleton in retrovirus assembly has long been speculated. However, specific mechanisms by which actin facilitates the assembly process remain elusive. We previously demonstrated differential effects of experimentally modified actin dynamics oil virion production of equine infectious anemia virus (EIAV), a lentivirus related to HIV-1, suggesting an involvement of actin dynamics in retrovirus production. In the current study, we used bimolecular fluorescence complementation (BiFC) to reveal intimate (