Predatory hunting and exposure to a live predator induce opposite patterns of Fos immunoreactivity in the PAG
Predatory hunting and exposure to a live predator induce opposite patterns of Fos immunoreactivity in the PAG
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DOI：
10.1016/s0166-4328(02)00197-3
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发表时间：
2003-01-06
影响因子：
2.7
通讯作者：
Canteras, NS
中科院分区：
文献类型：
--
作者：
Comoli, E;Ribeiro-Barbosa, ER;Canteras, NS
考虑到中脑导水管周围灰质(PAG)在调节动机反应中的一般作用，在本研究中，我们比较了相对动机驱动下的先天行为，即昆虫捕食和与活体捕食者(猫)对抗而诱发的防御行为在大鼠中脑导水管周围灰质中Fos的表达模式。暴露于捕食者与PAG内显著的Fos表达有关，在吻侧水平，Fos的表达主要分布在背内侧和背外侧区域，而在尾侧水平，Fos标记的细胞往往主要出现在外侧柱和腹外侧柱以及中缝背核。相反，昆虫捕食与Fos表达增加有关，主要是在外侧PAG的吻部三分之二，在那里大多数Fos免疫反应细胞被发现在动眼神经核水平。值得注意的是，猫和昆虫的捕食都上调了动眼上区和背外侧被盖核中Fos的表达。总体而言，目前的结果清楚地表明，PAG的激活模式似乎至少部分反映了动物的动机状态。众所周知，PAG对防御反应的表达是至关重要的，考虑到目前的发现，研究PAG如何促进捕食行为的表达也将是重要的。(C)2002 Elsevier Science B.V.保留所有权利。
Considering the periaqueductal gray's (PAG) general roles in mediating motivational responses, in the present study, we compared the Fos expression pattern in the PAG induced by innate behaviors underlain by opposite motivational drivers, in rats, namely, insect predation and defensive behavior evoked by the confrontation with a live predator (a cat). Exposure to the predator was associated with a striking Fos expression in the PAG, where, at rostral levels, an intense Fos expression was found largely distributed in the dorsomedial and dorsolateral regions, whereas, at caudal levels, Fos-labeled cells tended to be mostly found in the lateral and ventrolateral columns, as well as in the dorsal raphe nucleus. Quite the opposite, insect predation was associated with increased Fos expression predominantly in the rostral two thirds of the lateral PAG, where the majority of the Fos-immunoreactive cells were found at the oculomotor nucleus levels. Remarkably, both exposure to the cat and insect predation upregulated Fos expression in the supraoculomotor region and the laterodorsal tegmental nucleus. Overall, the present results clearly suggest that the PAG activation pattern appears to reflect, at least partly, the animal's motivational status. It is well established that the PAG is critical for the expression of defensive responses, and, considering the present findings, it will be important to investigate how the PAG contributes to the expression of the predatory behavior, as well. (C) 2002 Elsevier Science B.V. All rights reserved.