Behavioral effects of alpha-MSH and MCH after central administration in the female rat
Behavioral effects of alpha-MSH and MCH after central administration in the female rat
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DOI：
10.1016/0196-9781(95)02092-6
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发表时间：
1996-01-01
期刊：
影响因子：
3
通讯作者：
Wilson, CA
中科院分区：
文献类型：
--
作者：
Gonzalez, MI;Vaziri, S;Wilson, CA
研究了 α-MSH、MCH 和 α-MSH + MCH 在腹内侧核 (VMN) 和内侧视前区 (MPOA)（双侧，0.5 μl 中 100 ng）的行为效应。将 α-MSH 注入 VMN 会增加攻击行为；在 MPOA 中，它减少了探索并增加了焦虑。在这两个领域，它都刺激了性行为。 MCH 还刺激 MPOA 和 VMN 的性行为，并对 MPOA 产生焦虑作用。 α-MSH 对攻击性和探索性的影响被 MCH 拮抗。当同时给予时，这两种肽在焦虑方面相互拮抗。这项研究表明MCH具有中枢神经系统作用，可能是部分α-MSH激动剂。
The behavioral effects of alpha-MSH, MCH, and alpha-MSH + MCH were investigated in the ventromedial nucleus (VMN) and medial preoptic area (MPOA) (bilateral, 100 ng in 0.5 mu l). Infusion of alpha-MSH into the VMN increased aggressive behavior; in the MPOA it reduced exploration and increased anxiety. In both areas it stimulated sexual behavior. MCH also stimulated sexual behavior in the MPOA and VMN and had an anxiogenic effect in the MPOA. The effect of alpha-MSH on aggression and exploration was antagonized by MCH. When given together, the two peptides were mutually antagonistic on anxiety. This study indicates that MCH has central nervous system effects and may be a partial alpha-MSH agonist.