Adipose tissue is a regulated source of interleukin-10
Adipose tissue is a regulated source of interleukin-10
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DOI：
10.1016/j.cyto.2004.10.017
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发表时间：
2005-03-21
期刊：
影响因子：
3.8
通讯作者：
Meier, CA
中科院分区：
文献类型：
--
作者：
Juge-Aubry, CE;Somm, E;Meier, CA
白色脂肪组织（WAT）是促炎和抗炎细胞因子的来源，我们最近发现该组织是抗炎白细胞介素（IL）-1受体拮抗剂（IL-1 Ra）的主要来源。我们现在的目标是鉴定其他脂肪来源的细胞因子，它们可能作为IL-1 Ra的调节剂，我们在这里首次证明了人WAT外植体分泌的脂肪来源的细胞因子IL-10，并且它在体外被LPS和TNF-α上调，以及在人类肥胖中（皮下和内脏WAT分别增加2倍和6倍）和啮齿类动物（增加4倍）。(c)2005爱思唯尔有限公司保留所有权利。
White adipose tissue (WAT) is the source of pro- and anti-inflammatory cytokines and we have recently shown that this tissue is a major source of the anti-inflammatory interleukin (IL)-1 receptor antagonist (IL-1Ra). We now aimed at identifying additional adipose-derived cytokines, which might serve as regulators of IL-1Ra.We demonstrate here for the first time that the antiinflammatory cytokine IL-10 is secreted by human WAT explants and that it is up-regulated by LPS and TNF-alpha in vitro, as well as in obesity in humans (2- and 6-fold increase in subcutaneous and visceral WAT, respectively) and rodents (4-fold increase). (c) 2005 Elsevier Ltd. All rights reserved.