IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and γδ T cells in vivo
IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and γδ T cells in vivo
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DOI：
10.1182/blood-2008-12-192997
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发表时间：
2009-06-18
期刊：
影响因子：
20.3
通讯作者：
Min, Booki
中科院分区：
文献类型：
--
作者：
Do, Jeong-su;Min, Booki
外周T细胞亚群在体内维持的稳态机制在很大程度上仍然未知。在淋巴细胞减少的情况下使用T细胞增殖模型，我们现在证明γ δ T细胞限制CD 8 T细胞扩增，但不限制转移到淋巴细胞减少的受体后的初始增殖。由CD 11 c（+）树突状细胞（DCs）产生并在其膜上表达的白细胞介素-15（IL-15）是介导CD 8和γ δ T细胞之间稳态竞争的关键因子，揭示了体内不同T细胞亚群之间IL-15依赖的稳态机制。（血。2009; 113：6361-6371）
Homeostatic mechanism by which peripheral T-cell subsets are maintained in vivo remains largely unknown. Using a T-cell proliferation model under lymphopenic settings, we now demonstrate that gamma delta T cells limit CD8 T-cell expansion but not the initial proliferation after transfer into lymphopenic recipients. Interleukin-15 (IL-15) produced by and transpresented on the membrane of the CD11c(+) dendritic cells (DCs) is the key factor that mediates homeostatic competition between CD8 and gamma delta T cells, revealing previously unrecognized IL-15-dependent homeostatic mechanisms between different T-cell subsets in vivo. (Blood. 2009; 113: 6361-6371)