Cholinergic basal forebrain neurons burst with theta during waking and paradoxical sleep
Cholinergic basal forebrain neurons burst with theta during waking and paradoxical sleep
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DOI：
10.1523/jneurosci.0178-05.2005
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发表时间：
2005-04-27
影响因子：
5.3
通讯作者：
Jones, BE
中科院分区：
文献类型：
--
作者：
Lee, MG;Hassani, OK;Jones, BE
已知乙酰胆碱可以刺激大脑皮层的激活和促进可塑性，但尚不清楚在大脑皮层释放乙酰胆碱的胆碱能基底前脑神经元放电与自然皮质活动和睡眠觉醒状态的关系。通过记录睡眠-觉醒周期中与脑电活动相关的基本前脑单位，并用神经生物素标记单个神经元进行免疫组织化学鉴定，我们首次表明，胆碱能神经元在活跃的觉醒和反常睡眠期间以最大的速率放电，此时伽马和西塔脑电活动最大。在慢波睡眠期间，它们几乎停止发射。值得注意的是，它们的爆发式放电与theta振荡同步。在活跃的清醒和反常睡眠中，胆碱能神经元通过其最大的放电和节律性的theta放电，从而调节皮质，促进这两种状态下的激活和可塑性。
It is known that acetylcholine can stimulate activation and promote plasticity in the cerebral cortex, yet it is not known how the cholinergic basal forebrain neurons, which release acetylcholine in the cortex, discharge in relation to natural cortical activity and sleep - wake states. By recording basal forebrain units in association with electroencephalographic activity across the sleep - wake cycle and labeling individual neurons with Neurobiotin for immunohistochemical identification, we show for the first time that cholinergic neurons discharge in bursts at maximal rates during active waking and paradoxical sleep, when gamma and theta electroencephalographic activity are maximal. They virtually cease firing during slow-wave sleep. Notably, their bursting discharge is synchronized with theta oscillations. Through their maximal firing and rhythmic theta discharge during active waking and paradoxical sleep, the cholinergic neurons can thus modulate the cortex to promote activation along with plasticity during these two states.