The formation of N-nitrosomethyl(2-oxopropyl)amine from N-nitrosobis(2-oxopropyl)amine in vivo.
The formation of N-nitrosomethyl(2-oxopropyl)amine from N-nitrosobis(2-oxopropyl)amine in vivo.
复制标题
N-亚硝基双(2-氧代丙基)胺在体内形成N-亚硝基甲基(2-氧代丙基)胺。
DOI：
10.1093/carcin/2.9.845
复制
发表时间：
1981
期刊：
影响因子：
4.7
通讯作者：
D. Nagel
中科院分区：
文献类型：
--
作者：
T. Lawson;A. Helgeson;C. Grandjean;L. Wallcave;D. Nagel
雄性叙利亚金黄地鼠注射N-亚硝基双（2-氧代丙基）胺（BOP）（10 mg/kg）后，胰腺中BOP及其代谢产物的浓度高于肝脏和唾液腺。此外，在两种组织中均发现BOP的潜在甲基化代谢产物N-亚硝基甲基（2-氧代丙基）胺。
After injection of N-nitrosobis(2-oxopropyl)amine (BOP) (10 mg/kg) to male Syrian golden hamsters there were there concentrations of BOP and many of its metabolites in the hamster pancreas compared with the liver and salivary gland. Also, a potential methylating metabolite of BOP, N-nitrosomethyl(2-oxopropyl)amine, was found in both tissues.