Advancing Discovery of Snail Mucins Function and Application.
Advancing Discovery of Snail Mucins Function and Application.
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DOI：
10.3389/fbioe.2021.734023
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发表时间：
2021
影响因子：
5.7
通讯作者：
Holford M
中科院分区：
文献类型：
--
作者：
McDermott M;Cerullo AR;Parziale J;Achrak E;Sultana S;Ferd J;Samad S;Deng W;Braunschweig AB;Holford M
粘蛋白是一种高度糖化的蛋白质家族，由动物分泌，用于黏附、水合、润滑和其他功能。尽管它们无处不在，但动物粘蛋白在很大程度上是没有特征的。蜗牛在其粘液中产生粘蛋白，具有广泛的生物学功能，包括微生物保护、黏附和润滑。最近，蜗牛粘蛋白也成为了一个有利可图的创新来源，在化学、生物学、生物技术和生物医学中有着广泛的应用。具体地说，蜗牛粘液已被用作护肤品、伤口愈合剂、外科手术胶，并用于治疗胃溃疡。集成组学(基因组学、转录学、蛋白质组学、糖学)技术的最新进展改善了腹足类粘蛋白的特征，增加了新生物材料的产生。这一视角描述了目前对分泌蜗牛粘液的研究，突出了这种生物聚合物的潜力，并概述了一种研究策略，以满足尚未满足的检查导致蜗牛粘液基因具有巨大生物和化学多样性的层级结构的需求。
Mucins are a highly glycosylated protein family that are secreted by animals for adhesion, hydration, lubrication, and other functions. Despite their ubiquity, animal mucins are largely uncharacterized. Snails produce mucin proteins in their mucous for a wide array of biological functions, including microbial protection, adhesion and lubrication. Recently, snail mucins have also become a lucrative source of innovation with wide ranging applications across chemistry, biology, biotechnology, and biomedicine. Specifically, snail mucuses have been applied as skin care products, wound healing agents, surgical glues, and to combat gastric ulcers. Recent advances in integrated omics (genomic, transcriptomic, proteomic, glycomic) technologies have improved the characterization of gastropod mucins, increasing the generation of novel biomaterials. This perspective describes the current research on secreted snail mucus, highlighting the potential of this biopolymer, and also outlines a research strategy to fulfill the unmet need of examining the hierarchical structures that lead to the enormous biological and chemical diversity of snail mucus genes.