Use of the NASA Space Radiation Laboratory at Brookhaven National Laboratory to Conduct Charged Particle Radiobiology Studies Relevant to Ion Therapy.
Use of the NASA Space Radiation Laboratory at Brookhaven National Laboratory to Conduct Charged Particle Radiobiology Studies Relevant to Ion Therapy.
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DOI：
10.1667/rr14412.1
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发表时间：
2016-06
影响因子：
3.4
通讯作者：
Lowenstein DI
中科院分区：
文献类型：
--
作者：
Held KD;Blakely EA;Story MD;Lowenstein DI
尽管在日本和欧洲已经成功地进行了碳离子的临床研究，但关于比质子重的带电粒子的有限的放射生物学信息仍然是开发粒子治疗的全部潜力的重大障碍。在美国，人们越来越有兴趣建立一个利用比质子重的带电粒子的癌症治疗设施。因此，必须使用最先进的技术和生物模型以及与临床结果相关的终点获得额外的放射生物学知识。目前，大多数这样的离子放射治疗相关的研究是在美国以外进行的这篇文章解决了在美国宇航局空间辐射实验室（NSRL）在布鲁克海文国家实验室（BNL），这是唯一的设施在美国的研究可能作出的实质性贡献在这个时候，重离子放射生物学研究与感兴趣的离子种类和能量的治疗可以做。在这里，我们简要地讨论了NSRL的相关设施，以及如何选择带电粒子生物学研究的差距可以使用这些设施来解决。
Although clinical studies with carbon ions have been conducted successfully in Japan and Europe, the limited radiobiological information about charged particles that are heavier than protons remains a significant impediment to exploiting the full potential of particle therapy. There is growing interest in the U.S. to build a cancer treatment facility that utilizes charged particles heavier than protons. Therefore, it is essential that additional radiobiological knowledge be obtained using state-of-the-art technologies and biological models and end points relevant to clinical outcome. Currently, most such ion radiotherapy-related research is being conducted outside the U.S. This article addresses the substantial contributions to that research that are possible at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL), which is the only facility in the U.S. at this time where heavy-ion radiobiology research with the ion species and energies of interest for therapy can be done. Here, we briefly discuss the relevant facilities at NSRL and how selected charged particle biology research gaps could be addressed using those facilities.