Endogenous cannabinoids: Structure and metabolism
Endogenous cannabinoids: Structure and metabolism
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DOI：
10.1111/j.1365-2826.2008.01676.x
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发表时间：
2008-05-01
影响因子：
3.2
通讯作者：
Bisogno, T.
中科院分区：
文献类型：
--
作者：
Bisogno, T.
大麻的精神活性成分Delta(9)-四氢大麻酚的特异性结合位点的发现，导致了内源性大麻素系统的发现，并强调了内源性大麻素脂质信号的生理和病理相关性。随后，越来越多的关于内源性大麻素的生物化学和药理学的论文被发表。概述了目前对内源性大麻素的结构和代谢的理解，重点介绍了内源性大麻素的生物合成和失活机制。
The finding of specific binding sites for Delta(9)-tetrahydrocannabinol, the psychoactive component of Cannabis sativa, has led to the discovery of the endocannabinoid system and has emphasised the physiological and pathological relevance of endocannabidoid lipid signalling. Subsequently, an increasing number of papers have been published on the biochemistry and pharmacology of endocannabinoids. An overview of the current understanding of structure and metabolism of the best studied endocannabinoids is provided, with a focus on the mechanisms responsible for their biosynthesis and inactivation.