Frequencies of PrP genotypes in 38 breeds of sheep sampled in the National Scrapie Plan for Great Britain
Frequencies of PrP genotypes in 38 breeds of sheep sampled in the National Scrapie Plan for Great Britain
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DOI：
10.1136/vr.156.14.433
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发表时间：
2005-04-02
影响因子：
2.2
通讯作者：
Dawson, M
中科院分区：
文献类型：
--
作者：
Eglin, RD;Warner, R;Dawson, M
2001年10月至2003年1月之间的朊病毒蛋白（PrP）基因型超过250，000羊通过国家痒病计划（NSP）的操作进行了确定，38个品种的结果进行了分析，以提供一个估计的基础PrP基因型分布的英国绵羊种群。虽然不同品种的基因型谱之间存在明显的变异性，但出现了几种趋势。等位基因频率的比较结果表明，这些品种可分为三类：（ARR）和（ARQ）占优势的品种，其中ARR的频率超过ARQ的频率; ARR和ARQ占优势的品种，其中ARQ的频率超过ARR的频率; AHQ，ARH或VRQ的显着水平的品种。与其他品种相比，山丘品种更可能具有较低比例的羊瘙痒病低风险（NSP 1型）动物和较高比例的羊瘙痒病中等风险（NSP 3型）动物。大多数品种的羊瘙痒病（NSP 5型）高风险动物比例较小。ARR/VRQ（NSP 4型）的频率是可变的。
Between October 2001 and January 2003 the prion protein (PrP) genotypes of over 250,000 sheep were determined through the operation of the National Scrapie Plan (NSP); the results for 38 breeds were analysed to provide an estimate of the underlying PrP genotype distribution of the British sheep population. Although there was marked variability among the genotype profiles of the different breeds, several trends emerged. A comparison of the allele frequencies demonstrated that the breeds could be grouped into three categories: breeds dominated by (ARR) and (ARQ) in which the frequency Of ARR exceeded the frequency Of ARQ; breeds dominated by ARR and ARQ in which the frequency Of ARQ exceeded the frequency of ARR; and breeds with significant levels of either AHQ, ARH or VRQ. Hill breeds were more likely to have a lower proportion of animals at low risk of scrapie (NSP type 1) and a higher proportion of animals at an intermediate risk of scrapie (NSP type 3) than other breeds. Most breeds had a small proportion of animals at high risk of scrapie (NSP type 5). The frequency Of ARR/VRQ (NSP type 4.) was variable.