Is an early calcium flux necessary to stimulate lymphocytes?

Is an early calcium flux necessary to stimulate lymphocytes?
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刺激淋巴细胞是否需要早期钙通量？

DOI：
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发表时间：
1977
期刊：
Nature
影响因子：
64.8
通讯作者：
J. Metcalfe
J. Metcalfe
中科院分区：
综合性期刊1区
文献类型：
--
作者：
T. Hesketh;G. Smith;M. Houslay;G. B. Warren;J. Metcalfe

文献摘要

被引文献

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Concentrations of concanavalin A or the calcium ionophore A23187 that are optimal for the transformation of pig or mouse lymphocytes do not normally cause a measurable increase in calcium influx compared with unstimulated cells. If the cells are treated with the mitogens in conditions where a measurable increase in calcium influx occurs, no stimulation of the cells can occur while the flux is maintained. If any early influx of extracellular calcium is necessary for stimulation, then a much smaller increase in the total concentration of cellular calcium than reported previously is sufficient to allow the entry of lymphocytes into the cell cycle.