RISK-FACTORS FOR MALE BREAST-CANCER - A FRANCO-SWISS CASE-CONTROL STUDY
RISK-FACTORS FOR MALE BREAST-CANCER - A FRANCO-SWISS CASE-CONTROL STUDY
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DOI：
10.1002/ijc.2910450415
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发表时间：
1990-04-15
影响因子：
6.4
通讯作者：
AUQUIER, A
中科院分区：
文献类型：
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作者：
LENFANTPEJOVIC, MH;MLIKACABANNE, N;AUQUIER, A
为了评价男性乳腺癌的危险因素，在维勒瑞夫（法国）和日内瓦（瑞士）对91例组织学诊断病例和255例癌症对照进行了一项病例对照研究，年龄和诊断年份相匹配。研究的因素包括婚姻史、职业暴露、相关疾病、乳腺癌家族史、辐射暴露史和增加或怀疑增加催乳素或雌激素水平的药物。与对照组相比，病例组更有可能是单身汉或屠夫。其他有统计学意义的危险因素是乳腺癌家族史和洋地黄的治疗性使用。对于有结核病、甲状腺功能亢进症、肝硬化或胆结石病史、曾接受异烟肼治疗或在高温环境下工作的个人，观察到风险升高，尽管不显著。需要进一步的研究来证实我们的结果，特别是关于激素失衡和遗传因素。
In order to evaluate risk factors in male breast cancer, a case-control study of 91 histologically diagnosed cases and 255 cancer controls, matched for age and year of diagnosis, was conducted in Villejuif (France) and Geneva (Switzerland). Factors studied included marital history, occupational exposure, associated diseases, family history of breast cancer, history of radiation exposure and drugs which increase or are suspected of increasing prolactin or estrogen levels. Cases were significantly more likely to be bachelors or to work as butchers than were the controls. Other statistically significant risk factors identified were family history of breast cancer and therapeutic use of digitalis. Elevated risks, although not significant, were observed for individuals with a past history of tuberculosis, hyperthyoidism, liver cirrhosis or gallstone, who had been treated with isoniazid, or who had worked in high environmental temperatures. Further studies are needed to confirm our results particularly as regards hormonal imbalance and genetic factors.