Metabolic syndrome, insulin resistance, and periodontitis: a cross-sectional study in a middle-aged French population
Metabolic syndrome, insulin resistance, and periodontitis: a cross-sectional study in a middle-aged French population
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DOI：
10.1111/j.1600-051x.2010.01571.x
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发表时间：
2010-07-01
影响因子：
6.7
通讯作者：
Amar, Jacques
中科院分区：
文献类型：
--
作者：
Benguigui, Catherine;Bongard, Vanina;Amar, Jacques
P>目的代谢综合征由一系列临床和生物学异常组成，受胰岛素抵抗的影响并促进心血管疾病。我们研究了代谢综合征，其各种成分，胰岛素抵抗，和牙周炎之间的关系。Materials and MethodsThe study included 276例（35-74岁）招募内的横断面调查心血管危险因素。21例因感染风险或牙齿全失而被排除。记录临床附着丧失（CAL）、牙周袋探诊深度（PD）、牙龈指数和菌斑指数。牙周炎分为中度和重度forms.ResultsThe平均年龄为58，41%的受试者有中度和39%有严重的牙周炎。在单变量比较中，牙周炎与代谢综合征（p=0.050），其大部分成分，HOMA指数（胰岛素抵抗的稳态模型评估）。调整混杂因素后，只有HOMA指数仍与重度牙周炎相关（第三和第四个HOMA指数与第一个四分位数的比值比[OR]=3.97 [95%置信区间：1.22-12.9]，OR=3.78 [1.14-12.5]）。HOMA指数还与CAL >= 4 mm、CAL >= 5 mm或PD >= 4 mm的牙周部位数量相关（HOMA指数值越高，数量越多）。这种关系消失在never smokers.ConclusionsOur数据支持代谢紊乱和牙周炎之间的关系，胰岛素抵抗的核心作用。
P>AimMetabolic syndrome consists of a cluster of clinical and biological abnormalities, influenced by insulin resistance and promoting cardiovascular diseases. We examined the relationships between metabolic syndrome, its various components, insulin resistance, and periodontitis.Materials and MethodsThe study included 276 subjects (35-74 years) recruited within a cross-sectional survey on cardiovascular risk factors. Twenty-one were excluded because of infectious risk or total tooth loss. Clinical attachment loss (CAL), probing pocket depth (PD), gingival and plaque indexes were recorded. Periodontitis was classified into moderate and severe forms.ResultsThe mean age was 58, 41% of the subjects had moderate and 39% had severe periodontitis. In univariate comparisons, periodontitis was associated with metabolic syndrome (p=0.050), most of its components, and HOMA index (homoeostasis model assessment of insulin resistance). After adjustment for confounders, only HOMA index remained associated with severe periodontitis (odds ratio [OR]=3.97 [95% confidence interval: 1.22-12.9], OR=3.78 [1.14-12.5] for third and fourth versus the first quartile of the HOMA index, respectively). The HOMA index was also associated with the number of periodontal sites with CAL >= 4 mm, CAL >= 5 mm, or PD >= 4 mm (greater number for higher HOMA-index values). This relationship disappeared in never-smokers.ConclusionsOur data support the relationships between metabolic disturbances and periodontitis, with a central role of insulin resistance.