Treating bacterial virulence systems: we are not there yet.
Treating bacterial virulence systems: we are not there yet.
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治疗细菌毒力系统：我们还没有做到这一点。
DOI：
10.1007/s00134-012-2561-9
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发表时间：
2012
影响因子：
38.9
通讯作者：
Wiener-Kronish,Jeanine
中科院分区：
文献类型：
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作者：
Huang,YvonneJ;Bittner,EdwardA;Frank,Dara;Wiener-Kronish,Jeanine
在van Delden及其同事的手稿[1]中，声称阿奇霉素成功地抑制了群体感应(QS)，并降低了铜绿假单胞菌呼吸机相关肺炎(VAP)的发生率。这一结论掩盖了在被定植并最终感染铜绿假单胞菌的患者中发生的事情的复杂性。在van Delden和他的同事在Thorax[2]的早期发表的一篇文章中，从研究患者的子集(见下文)中获得了320个铜绿假单胞菌分离物；他们在20天内收集了29名患者的分离物。有趣的是，只有7/29(24%)的患者有“精通QS的菌株”，并且这些患者中只有4人发展为VAP。事实上，大多数患者是由QS缺陷的铜绿假单胞菌分离株定植的。VAP的发生率更多地发生在
In the manuscript by van Delden and colleagues [1], the claim is made that azithromycin was successful in inhibiting quorum sensing (QS) and decreased the incidence of Pseudomonas aeruginosa-ventilator-associated pneumonia (VAP). This conclusion belies the complexity of what happens in patients colonized and ultimately infected by P. aeruginosa.In an earlier publication by van Delden and colleagues in Thorax [2], 320 P. aeruginosa isolates were obtained from a subset of the study patients (see below); they collected isolates from 29 patients over 20 days. Interestingly, only 7/29 (24%) patients had ‘‘QS-proficient isolates’’, and only four of these patients developed VAP. In fact, the majority of patients were colonized by QS-deficient P. aeruginosa isolates. VAP occurred more frequently in patients colonized during the entire