Periodontal bacteria and hypertension: the oral infections and vascular disease epidemiology study (INVEST).
Periodontal bacteria and hypertension: the oral infections and vascular disease epidemiology study (INVEST).
复制标题
DOI：
10.1097/hjh.0b013e328338cd36
复制
发表时间：
2010-07
影响因子：
4.9
通讯作者：
Papapanou PN
中科院分区：
文献类型：
--
作者：
Desvarieux M;Demmer RT;Jacobs DR Jr;Rundek T;Boden-Albala B;Sacco RL;Papapanou PN
慢性感染，包括牙周感染，可能诱发心血管疾病。我们研究了牙周微生物群与高血压之间的关系。方法和结果：653 名无中风或心肌梗塞病史的有齿男性和女性被纳入 INVEST。我们收集了 4533 个龈下菌斑样本（平均每个受试者 7 个样本）。使用 DNA-DNA 棋盘杂交对 11 种牙周细菌进行了定量评估。获得心血管危险因素测量值。血压和高血压（收缩压≥140 mmHg，舒张压≥90 mmHg或服用抗高血压药物，或自我报告病史）分别在细菌水平上回归：（1）被认为是牙周病的病因（病因细菌负荷）； (2) 与牙周病相关（推定的细菌负荷）； (3)与牙周健康相关(health-linkedbacterialload)。所有分析均根据年龄、种族/民族、性别、教育程度、体重指数、吸烟、糖尿病、低密度脂蛋白和高密度脂蛋白胆固醇进行调整。病因细菌负荷与血压和高血压患病率呈正相关。比较病因细菌负荷的最高与最低三分位数，SBP 升高 9 mmHg，DBP 升高 5 mmHg（每种情况下线性趋势 p <0.001），多变量调整后，流行性高血压的比值比为 3.05 (95%CI:1.60,5.82)。我们的数据提供了龈下牙周细菌水平与收缩压和舒张压以及高血压患病率之间直接关系的证据。
Chronic infections, including periodontal infections, may predispose to cardiovascular disease. We investigated the relationship between periodontal microbiota and hypertension. Methods and Results: 653 dentate men and women with no history of stroke or myocardial infarction were enrolled in INVEST. We collected 4533 subgingival plaque samples (average of 7 samples/subject). These were quantitatively assessed for 11 periodontal bacteria using DNA-DNA checkerboard hybridization. Cardiovascular risk factor measurements were obtained. Blood pressure and hypertension (systolic blood pressure≥140 mmHg, diastolic blood pressure≥90 mmHg or taking antihypertensive medication, or self-reported history) were each regressed on the level of bacteria: (1) considered causative of periodontal disease (etiologic bacterial burden); (2) associated with periodontal disease (putative bacterial burden); (3) associated with periodontal health (health associated bacterial burden). All analyses were adjusted for age, race/ethnicity, gender, education, body mass index, smoking, diabetes, LDL and HDL cholesterol. Etiologic bacterial burden was positively associated with both blood pressure and prevalent hypertension. Comparing the highest vs. lowest tertiles of etiologic bacterial burden, SBP was 9 mmHg higher, DBP was 5 mmHg higher (p for linear trend <0.001 in each case), and the odds ratio for prevalent hypertension was 3.05 (95%CI:1.60,5.82) after multivariable adjustment. Our data provide evidence of a direct relationship between the levels of subgingival periodontal bacteria and both systolic and diastolic blood pressure as well as hypertension prevalence.