Alopecia areata is characterized by expansion of circulating Th2/Tc2/Th22, within the skin-homing and systemic T-cell populations
Alopecia areata is characterized by expansion of circulating Th2/Tc2/Th22, within the skin-homing and systemic T-cell populations
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DOI：
10.1111/all.13346
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发表时间：
2018-03-01
期刊：
影响因子：
12.4
通讯作者：
Guttman-Yassky, E.
中科院分区：
文献类型：
--
作者：
Czarnowicki, T.;He, H. Y.;Guttman-Yassky, E.
背景描述斑秃 (AA) 的血液特征不仅对于治疗进展很重要，而且对于可能识别外周生物标志物，从而消除头皮活检的需要也很重要。我们的目的是比较 AA 与特应性皮炎 (AD) 和对照血液中皮肤归巢 (CLA(+)) 与全身 (CLA(-)) 极性 CD4(+) 和 CD8(+) 以及活化 T 细胞亚群的频率。方法采用流式细胞术测量 CD4(+) 和 CD8(+) T 细胞中的 IFN-、IL-13、IL-9、IL-17 和 IL-22 细胞因子。诱导共刺激分子 (ICOS) 和 HLA-DR 用于定义中长期 T 细胞激活。我们比较了 32 名中重度 AA 成人与 43 名中重度 AD 患者和 30 名年龄匹配的对照者的外周血。结果 AA 患者的 CLA(+)/CLA(-) Th2 升高（P
BackgroundCharacterizing blood profile of alopecia areata (AA) is important not only for treatment advancements, but also for possibly identifying peripheral biomarkers that will eliminate the need for scalp biopsies. We aimed to compare frequencies of skin homing (CLA(+)) vs systemic (CLA(-)) polar CD4(+) and CD8(+) and activated T-cell subsets in AA vs atopic dermatitis (AD) and control blood.MethodsFlow cytometry was used to measure IFN-, IL-13, IL-9, IL-17, and IL-22 cytokines in CD4(+) and CD8(+) T cells. Inducible co-stimulator molecule (ICOS) and HLA-DR were used to define mid- and long-term T-cell activation. We compared peripheral blood from 32 moderate-to-severe AA adults with 43 moderate-to-severe AD patients and 30 age-matched controls.ResultsAA patients had increased CLA(+)/CLA(-) Th2 (P