PARVALBUMIN IN MOST GAMMA-AMINOBUTYRIC-ACID CONTAINING NEURONS OF THE RAT CEREBRAL-CORTEX
PARVALBUMIN IN MOST GAMMA-AMINOBUTYRIC-ACID CONTAINING NEURONS OF THE RAT CEREBRAL-CORTEX
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DOI：
10.1126/science.3945815
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发表时间：
1986-02-28
期刊：
影响因子：
56.9
通讯作者：
CELIO, MR
中科院分区：
文献类型：
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作者：
CELIO, MR
γ-氨基丁酸（GABA）是中枢神经系统中主要的抑制性神经递质之一。在大脑皮层中，含有 GABA 的细胞代表中间神经元的一个亚群。利用半薄冰冻切片，可以证明大鼠体感皮层中的大多数 GABA 神经元含有钙结合蛋白小清蛋白，并且小清蛋白实际上只存在于 GABA 神经元中。小清蛋白似乎会影响电特性和酶机制来调节神经元的兴奋性和活动。小清蛋白在含 GABA 的皮质细胞中的具体作用可能与控制其抑制作用的有效性有关。
.gamma.-Aminobutyric acid (GABA) is one of the major inhibitory neurotransmitters in the central nervous system. In the cerebral cortex, GABA-containing cells represent a subpopulation of interneurons. With semithin frozen sections, it is possible to demonstrate that most GABA neurons in the rat somatosensory cortex contain the calcium-binding protein parvalbumin and that parvalbumin is found virtually only in GABA neurons. Parvalbumin seems to influence the electrical properties and enzymatic machinery to modulate neuronal excitability and activity. The specific role of parvalbumin in GABA-containing cortical cells may be related to controlling the effectiveness of their inhibitory action.