Association between weekly exercise minutes and resting IL-6 in adults with chronic spinal cord injury: findings from the fracture risk after spinal cord injury exercise study.
Association between weekly exercise minutes and resting IL-6 in adults with chronic spinal cord injury: findings from the fracture risk after spinal cord injury exercise study.
复制标题
慢性脊髓损伤成人每周运动分钟数与静息 IL-6 之间的关联：脊髓损伤运动研究后骨折风险的发现。
DOI：
10.1038/s41393-022-00833-7
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发表时间：
2022
期刊：
影响因子：
2.2
通讯作者：
Morse,LeslieR
中科院分区：
文献类型：
--
作者：
Park,Andrew;Ryder,Stephanie;Sevigny,Mitch;Monden,KimberleyR;Battaglino,RicardoA;Nguyen,Nguyen;Goldstein,Richard;Morse,LeslieR
研究设计横断面研究。目的评估每周有氧运动分钟数与慢性脊髓损伤(SCI)成人静息白介素6(IL-6)、C反应蛋白(CRP)和瘦素水平的关系。吸烟、用药、合并症和每周有氧运动分钟数通过自填式问卷进行评估。采用全身双能X线骨密度仪测定人体成分。结果在多变量模型中，每周有氧运动每1 分钟静息IL-6水平降低0.001 pg/m L。IL-6水平随着Android-Gynoid脂肪比例的增加而增加，活跃吸烟者/曾经吸烟者与从不吸烟者相比，以及有皮肤压力损伤的人与不吸烟者相比。主动使用布洛芬的患者IL-6水平低于未使用布洛芬的患者。在设计类似的模型时，我们发现每周运动分钟数与CRP或瘦素没有相关性。结论考虑到身体成分、吸烟、皮肤压力损伤和布洛芬的使用，慢性脊髓损伤患者每周有氧运动分钟数的增加与IL-6水平的降低有关。当考虑相似的变量时，C反应蛋白和瘦素没有显示出与运动有关。使用这些生物标记物评估未来运动相关干预措施的治疗价值，对于有意义地改善脊髓损伤患者的健康状况将是至关重要的。尽管这是一个大型的前瞻性数据集，但这项横断面研究不能确定因果关系。需要未来的前瞻性研究来证实这些发现。
Study designCross-sectional study.ObjectiveTo assess associations between weekly aerobic exercise minutes and resting interleukin-6 (IL-6), C-reactive protein (CRP), or leptin levels in adults with chronic spinal cord injury (SCI).SettingThree hundred and forty-four community-dwelling men and women with SCI duration of > 1 year.MethodsCRP, IL-6, and leptin levels were quantified by ultra-sensitive enzyme-linked immunoassay. Smoking, medication use, comorbidities, and aerobic exercise minutes per week were assessed by self-reported questionnaire. Body composition was determined by whole-body dual-energy X-ray absorptiometry. Generalized linear models were used to assess associations.ResultsIn multivariable modeling, resting IL-6 levels were 0.001 pg/mL lower for every 1 min of weekly aerobic exercise. IL-6 levels increased with increasing android-to-gynoid fat ratio, in active/ever smokers compared to never smokers, and in individuals with skin pressure injuries compared to those without. IL-6 levels were lower in active ibuprofen users compared to nonusers. We found no association between weekly exercise minutes and CRP or leptin when designing similar models.ConclusionsIncreasing aerobic exercise minutes is associated with lower IL-6 levels in adults with chronic SCI when considering body composition, smoking, skin pressure injuries, and ibuprofen use. CRP and leptin did not demonstrate an association with exercise when considering the similar variables. The use of these biomarkers in assessing the therapeutic value of future exercise-related interventions will be paramount for meaningful health improvement among those with SCI. Although a large, prospective dataset, this cross-sectional study cannot assign causation. Future prospective studies are needed to confirm these findings.