Medical management of brain tumors and the sequelae of treatment
Medical management of brain tumors and the sequelae of treatment
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DOI：
10.1093/neuonc/nou304
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发表时间：
2015-04-01
期刊：
影响因子：
15.9
通讯作者：
Wen, Patrick Y.
中科院分区：
文献类型：
--
作者：
Schiff, David;Lee, Eudocia Q.;Wen, Patrick Y.
恶性脑肿瘤患者容易出现并发症，这些并发症会对他们的生活质量产生负面影响，有时还会影响他们的总体生存率。肿瘤可能直接引起癫痫发作、高凝状态并导致静脉血栓栓塞以及情绪和认知障碍。抗肿瘤治疗和支持疗法也会产生副作用。在这篇综述中，我们讨论了恶性脑肿瘤患者支持性治疗的主要方面，特别关注癫痫发作、静脉血栓栓塞、皮质类固醇及其并发症、化疗（包括贝伐单抗）以及疲劳、情绪和认知功能障碍的管理。
Patients with malignant brain tumors are prone to complications that negatively impact their quality of life and sometimes their overall survival as well. Tumors may directly provoke seizures, hypercoagulable states with resultant venous thromboembolism, and mood and cognitive disorders. Antitumor treatments and supportive therapies also produce side effects. In this review, we discuss major aspects of supportive care for patients with malignant brain tumors, with particular attention to management of seizures, venous thromboembolism, corticosteroids and their complications, chemotherapy including bevacizumab, and fatigue, mood, and cognitive dysfunction.