Cross-regulation in Vibrio parahaemolyticus:: Compensatory activation of polar flagellar genes by the lateral flagellar regulator LafK
Cross-regulation in Vibrio parahaemolyticus:: Compensatory activation of polar flagellar genes by the lateral flagellar regulator LafK
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DOI：
10.1128/jb.186.12.4014-4018.2004
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发表时间：
2004-06-01
影响因子：
3.2
通讯作者：
McCarter, LL
中科院分区：
文献类型：
--
作者：
Kim, YK;McCarter, LL
副溶血性弧菌、霍乱弧菌和铜绿假单胞菌的极鞭毛基因的基因组织和分级调控似乎高度相似，但有一个令人困惑的差异。在霍乱弧菌和铜绿假单胞菌中，需要两种sigma（54）依赖性调节因子来指导不同类型的中间鞭毛基因表达，而这些调节因子之一FlaK的副溶血性弧菌同源物似乎是不相关的。在这里，我们表明，有补偿激活极鞭毛基因的侧鞭毛调节LafK。
Gene organization and hierarchical regulation of the polar flagellar genes of Vibrio parahaemolyticus, Vibrio cholerae, and Pseudomonas aeruginosa appear highly similar, with one puzzling difference. Two sigma(54)-dependent regulators are required to direct different classes of intermediate flagellar gene expression in V. cholerae and P. aeruginosa, whereas the V. parahaemolyticus homolog of one of these regulators, FlaK, appears dispensable. Here we demonstrate that there is compensatory activation of polar flagellar genes by the lateral flagellar regulator LafK.