Sensory nerves protect from the progression of early stage osteoarthritis in mice
Sensory nerves protect from the progression of early stage osteoarthritis in mice
复制标题
感觉神经可以保护小鼠免受早期骨关节炎的进展。
DOI：
10.1080/03008207.2019.1611796
复制
发表时间：
2020
影响因子：
2.9
通讯作者：
Luo Zong Ping
中科院分区：
文献类型：
--
作者：
Shao Yi Jie;Chen Xi;Chen Zhi;Jiang Hua Ye;Zhong Dong Yan;Wang Yi Fan;Yang Hui Lin;Saijilafu;Luo Zong Ping
PurposeOsteoarthritis (OA) is a chronic degenerative joint disease. Sensory nerves play an important role in bone metabolism and in the progression of inflammation. This study explored the effects of sensory nerve on OA progression at early stage in mice.Materials and MethodsOA was induced via destabilization of the medial meniscus (DMM) in C57BL/6 mice. Sensory denervation was induced by subcutaneous injection of capsaicin (90 mg/kg) one week prior to DMM. One week after capsaicin injection, sensory denervation in the tibia was confirmed by immunofluorescent staining. Four weeks after DMM, micro-CT scans, histological analysis, and RT-PCR tests were performed to evaluate OA progression.ResultsSubcutaneous injection of capsaicin successfully induced sensory denervation in tibia. The Osteoarthritis Research Society International (OARSI) score and synovitis score of the capsaicin+DMM group were significantly higher than the score of the vehicle+DMM group. The BV/TV of the tibial subchondral bone in the capsaicin+DMM group was significantly lower than in the vehicle+DMM group. In addition, the level of expression of inflammatory factors in the capsaicin+DMM group was significantly higher than in the vehicle+DMM group.ConclusionsCapsaicin-induced sensory denervation accelerated OA progression at early stage in mice. To put it another way, sensory nerve protects from OA progression at early stage in mice.
