Elevated cardiovascular risk among adults with obstructive and restrictive airway functioning in the United States: a cross-sectional study of the National Health and Nutrition Examination Survey from 2007-2010.
Elevated cardiovascular risk among adults with obstructive and restrictive airway functioning in the United States: a cross-sectional study of the National Health and Nutrition Examination Survey from 2007-2010.
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DOI：
10.1186/1465-9921-13-115
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发表时间：
2012-12-13
影响因子：
5.8
通讯作者：
Croft JB
中科院分区：
文献类型：
--
作者：
Ford ES;Wheaton AG;Mannino DM;Presley-Cantrell L;Li C;Croft JB
慢性阻塞性肺疾病患者心血管疾病风险过高的原因尚不清楚。我们的目的是在美国成年人的代表性样本中，研究阻塞性和限制性肺功能障碍的成年人的心血管风险特征。我们使用了2007年至2010年参加国家健康和营养检查调查并进行肺功能检查的20-79岁成年人的数据。阻塞性肺损伤的严重程度是通过调整全球慢性阻塞性肺疾病标准来定义的。在7249名参与者中，80.9%的肺功能检查正常，5.7%有限制性损害，7.9%有轻度阻塞性损害，5.5%有中度或重度/极重度阻塞性损害。阻塞性损害的参与者吸烟率高，血清可替宁浓度升高。与肺功能正常的参与者相比，至少中度阻塞性损害的参与者C反应蛋白浓度升高，但总胆固醇和非高密度脂蛋白胆固醇浓度较低。在50-74岁的参与者中，至少有中度阻塞性损害或限制性损害的参与者预测的10年心血管疾病风险升高。肺功能受损的成年人吸烟率很高，特别是阻塞性肺功能受损的成年人，这表明需要积极努力促进这些成年人戒烟。此外，限制性损伤的成年人可能需要更多的关注和微调他们的心血管风险状况。
Reasons for the excess risk for cardiovascular disease among people with chronic obstructive pulmonary disease remain unclear. Our objective was to examine the cardiovascular risk profile for adults with obstructive and restrictive impairments of lung functioning in a representative sample of adults from the United States. We used data from adults aged 20–79 years who participated in the National Health and Nutrition Examination Survey from 2007 to 2010 and had a pulmonary function test. The severity of obstructive impairment was defined by adapting the Global Initiative for Chronic Obstructive Lung Disease criteria. Among 7249 participants, 80.9% had a normal pulmonary function test, 5.7% had a restrictive impairment, 7.9% had mild obstructive impairment, and 5.5% had moderate or severe/very severe obstructive impairment. Participants with obstructive impairment had high rates of smoking and increased serum concentrations of cotinine. Compared to participants with normal pulmonary functioning, participants with at least moderate obstructive impairment had elevated concentrations of C-reactive protein but lower concentrations of total cholesterol and non-high-density lipoprotein cholesterol. Among participants aged 50–74 years, participants with at least a moderate obstructive impairment or a restrictive impairment had an elevated predicted 10-year risk for cardiovascular disease. The high rates of smoking among adults with impaired pulmonary functioning, particularly those with obstructive impairment, point to a need for aggressive efforts to promote smoking cessation in these adults. In addition, adults with restrictive impairment may require increased attention to and fine-tuning of their cardiovascular risk profile.
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影响因子：
24.3
作者：
Hansell, AL;Walk, JA;Soriano, JB
通讯作者：
Soriano, JB
影响因子：
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Celli, Bartolome;Decramer, Marc;Tashkin, Donald P.
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作者：
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