Rethinking schizophrenia
Rethinking schizophrenia
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DOI：
10.1038/nature09552
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发表时间：
2010-11-11
期刊：
影响因子：
64.8
通讯作者：
Insel, Thomas R.
中科院分区：
文献类型：
--
作者：
Insel, Thomas R.
到2030年我们将如何看待精神分裂症？如今，精神分裂症是一种慢性的、常常导致残疾的精神障碍，影响着全球约1%的人口。经过一个世纪对精神分裂症的研究，其病因仍然不明。治疗方法，尤其是药物治疗，已经广泛应用了近半个世纪，但几乎没有证据表明这些治疗方法对大多数精神分裂症患者的治疗效果有实质性的改善。随着我们将精神分裂症视为一种神经发育障碍，而精神病是该疾病后期一个可能可预防的阶段，目前这些不尽如人意的治疗结果可能会改变。将精神分裂症重新视为一种神经发育障碍，这与我们在过去一个世纪看待这种疾病的方式截然不同，这为未来二十年的预防和治愈带来了新的希望。
How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently disabling mental disorder that affects about one per cent of the world's population. After a century of studying schizophrenia, the cause of the disorder remains unknown. Treatments, especially pharmacological treatments, have been in wide use for nearly half a century, yet there is little evidence that these treatments have substantially improved outcomes for most people with schizophrenia. These current unsatisfactory outcomes may change as we approach schizophrenia as a neurodevelopmental disorder with psychosis as a late, potentially preventable stage of the illness. This 'rethinking' of schizophrenia as a neurodevelopmental disorder, which is profoundly different from the way we have seen this illness for the past century, yields new hope for prevention and cure over the next two decades.